Living Donor Liver Transplantation for Acute Liver Failure: Donor Safety and Recipient Outcome

Viniyendra Pamecha, Ankur Vagadiya, Piyush Kumar Sinha, Rommel Sandhyav, Kumaraswamy Parthasarathy, Shridhar Sasturkar, Nihar Mohapatra, Ashok Choudhury, Rakhi Maiwal, Rajeev Khanna, Seema Alam, Chandra Kant Pandey, Shiv Kumar Sarin – 12 March 2019 – In countries where deceased organ donation is sparse, emergency living donor liver transplantation (LDLT) is the only lifesaving option in select patients with acute liver failure (ALF). The aim of the current study is living liver donor safety and recipient outcomes following LDLT for ALF.

Adipose‐Specific Lipin‐1 Overexpression Renders Hepatic Ferroptosis and Exacerbates Alcoholic Steatohepatitis in Mice

Zhou Zhou, Ting Jie Ye, Gregory Bonavita, Michael Daniels, Noah Kainrad, Alvin Jogasuria, Min You – 12 March 2019 – Lipin‐1 is a Mg2+‐dependent phosphatidic acid phosphohydrolase involved in the generation of diacylglycerol during synthesis of phospholipids and triglycerides. Ethanol‐mediated inhibitory effects on adipose‐specific lipin‐1 expression were associated with experimental steatohepatitis in rodents.

Effect of a Multistrain Probiotic on Cognitive Function and Risk of Falls in Patients With Cirrhosis: A Randomized Trial

Eva Román, Juan Camilo Nieto, Cristina Gely, Sílvia Vidal, Marta Pozuelo, Maria Poca, Cándido Juárez, Carlos Guarner, Chaysavanh Manichanh, Germán Soriano – 12 March 2019 – Probiotics can modulate gut microbiota, intestinal permeability, and immune response and could therefore improve cognitive dysfunction and help avoid potential consequences, such as falls, in patients with cirrhosis. The aim of this study was to evaluate the effect of a multistrain probiotic on cognitive function, risk of falls, and inflammatory response in patients with cirrhosis.

Collagen Formation Assessed by N‐Terminal Propeptide of Type 3 Procollagen Is a Heritable Trait and Is Associated With Liver Fibrosis Assessed by Magnetic Resonance Elastography

Cyrielle Caussy, Meera Bhargava, Ida F. Villesen, Natasja S. Gudmann, Diana J. Leeming, Morten A. Karsdal, Claire Faulkner, Denny Bao, Amy Liu, Min‐Tzu Lo, Ricki Bettencourt, Shirin Bassirian, Lisa Richards, David A. Brenner, Chi‐Hua Chen, Claude B. Sirlin, Rohit Loomba – 12 March 2019 – N‐terminal propeptide of type 3 procollagen (PRO‐C3) is a biomarker of liver fibrosis in nonalcoholic fatty liver disease (NAFLD).

Home‐Based Exercise in Patients Awaiting Liver Transplantation: A Feasibility Study

Felicity Rhian Williams, Alice Vallance, Thomas Faulkner, Jennifer Towey, Simon Durman, Derek Kyte, Ahmed Mohamed Elsharkawy, Thamara Perera, Andrew Holt, James Ferguson, Janet M. Lord, Matthew James Armstrong – 11 March 2019 – Frailty is associated with increased mortality both before and after liver transplantation (LT). There are no standardized exercise programs, in particular home‐based exercise programs (HBEPs), for patients awaiting LT. The aim was to investigate the feasibility of such a program in patients awaiting LT.

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