Blocking Triggering Receptor Expressed on Myeloid Cells‐1‐Positive Tumor‐Associated Macrophages Induced by Hypoxia Reverses Immunosuppression and Anti‐Programmed Cell Death Ligand 1 Resistance in Liver Cancer

Qinchuan Wu, Wuhua Zhou, Shengyong Yin, Yuan Zhou, Tianchi Chen, Junjie Qian, Rong Su, Liangjie Hong, Haohao Lu, Feng Zhang, Haiyang Xie, Lin Zhou, Shusen Zheng – 27 February 2019 – Tumor‐associated macrophages (TAMs) are recognized as antitumor suppressors, but how TAMs behave in the hypoxic environment of hepatocellular carcinoma (HCC) remains unclear. Here, we demonstrated that hypoxia inducible factor 1α induced increased expression of triggering receptor expressed on myeloid cells‐1 (TREM‐1) in TAMs, resulting in immunosuppression.

Hepatology Highlights

Omar Mousa, Harmeet Malhi, Robert E. Schwartz, Tasha B. Kulai, Hirsh D. Trivedi, Daryl T.Y. Lau, Nicole T. Shen, Robert S. Brown, Petra Hirsova, Xu Xu, Hayley T. Nicholls, Joseph F. Pisa, Zaid H. Tafesh, Brett E. Fortune, Vikas Gupta, Enis Kostallari, Nicholas Russo, Arun B. Jesudian – 27 February 2019

Hepatology Highlights

Omar Mousa, Harmeet Malhi, Robert E. Schwartz, Tasha B. Kulai, Hirsh D. Trivedi, Daryl T.Y. Lau, Nicole T. Shen, Robert S. Brown, Petra Hirsova, Xu Xu, Hayley T. Nicholls, Joseph F. Pisa, Zaid H. Tafesh, Brett E. Fortune, Vikas Gupta, Enis Kostallari, Nicholas Russo, Arun B. Jesudian – 27 February 2019

Radiotherapy for Hepatocellular Carcinoma Results in Comparable Survival to Radiofrequency Ablation: A Propensity Score Analysis

Koji Hara, Atsuya Takeda, Yuichiro Tsurugai, Yusuke Saigusa, Naoko Sanuki, Takahisa Eriguchi, Shin Maeda, Katsuaki Tanaka, Kazushi Numata – 25 February 2019 – Potentially curative treatments for early‐stage hepatocellular carcinoma (HCC) have drawbacks and contraindications. Recently, radiotherapy has achieved good outcomes. We compared the outcomes of radiotherapy and radiofrequency ablation (RFA) for early‐stage HCC. Consecutive patients with ≤3 early‐stage HCC lesions and tumor diameters ≤3 cm treated with RFA or radiotherapy were reviewed.

Angiopoietin‐2/Tie2 Inhibition by Regorafenib Associates With Striking Response in a Patient With Aggressive Hepatocellular Carcinoma

Paola Todesca, Luca Marzi, Rosina Maria Critelli, Biagio Cuffari, Cristian Caporali, Laura Turco, Giovanni Pinelli, Filippo Schepis, Lucia Carulli, Nicola de Maria, Federico Casari, Riccardo Scaglioni, Erica Villa – 25 February 2019

A Call to Standardize Definitions, Data Collection, and Outcome Assessment to Improve Care in Alcohol‐Related Liver Disease

Nicole T. Shen, Annaheta Salajegheh, Robert S. Brown – 25 February 2019 – Alcohol‐related liver disease (ALD) is highly prevalent and appears to be increasingly reported with worsening mortality; thus, optimizing care in this patient population is imperative. This will require a multidisciplinary, multifaceted approach that includes recognizing alcohol use disorder (AUD) and existing treatments for AUD. We must also acknowledge the full spectrum of ALD clinically and histologically.

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