The Capicua/ETS Translocation Variant 5 Axis Regulates Liver‐Resident Memory CD8+ T‐Cell Development and the Pathogenesis of Liver Injury
Sungjun Park, Jiho Park, Eunjeong Kim, Yoontae Lee – 27 February 2019 – Liver‐resident memory T (liver TRM) cells exert protective immune responses following liver infection by malaria parasites. However, how these TRM cells are developed and what the consequence is if they are not properly maintained remain poorly understood. Here, we show that the transcriptional repressor, Capicua (CIC), controls liver CD8+ TRM cell development to maintain normal liver function.