Role of the Gut–Liver Axis in Liver Inflammation, Fibrosis, and Cancer: A Special Focus on the Gut Microbiota Relationship

Naoko Ohtani, Norifumi Kawada – 1 March 2019 – The gut and the liver are anatomically and physiologically connected, and this “gut–liver axis” exerts various influences on liver pathology. The gut microbiota consists of various microorganisms that normally coexist in the human gut and have a role of maintaining the homeostasis of the host. However, once homeostasis is disturbed, metabolites and components derived from the gut microbiota translocate to the liver and induce pathologic effects in the liver.

Reply

Fei Wang, Jing Wang, Yaru Li, Jing Yuan, Ping Yao, Sheng Wei, Huan Guo, Xiaomin Zhang, Handong Yang, Tangchun Wu, Meian He – 1 March 2019

Dual Specificity Phosphatase 12 Regulates Hepatic Lipid Metabolism Through Inhibition of the Lipogenesis and Apoptosis Signal–Regulating Kinase 1 Pathways

Zhen Huang, Lei‐Ming Wu, Jie‐Lei Zhang, Abdelkarim Sabri, Shou‐Jun Wang, Gui‐Jun Qin, Chang‐Qing Guo, Hong‐Tao Wen, Bin‐Bin Du, Dian‐Hong Zhang, Ling‐Yao Kong, Xin‐Yu Tian, Rui Yao, Ya‐Peng Li, Cui Liang, Peng‐Cheng Li, Zheng Wang, Jin‐Yan Guo, Ling Li, Jian‐Zeng Dong, Yan‐Zhou Zhang – 1 March 2019 – Nonalcoholic fatty liver disease (NAFLD) has become the most common cause of chronic liver disease worldwide. Due to the growing economic burden of NAFLD on public health, it has become an emergent target for clinical intervention.

Manipulation of Lipid Metabolism During Normothermic Machine Perfusion: Effect of Defatting Therapies on Donor Liver Functional Recovery

Yuri L. Boteon, Joseph Attard, Amanda P. C. S. Boteon, Lorraine Wallace, Gary Reynolds, Stefan Hubscher, Darius F. Mirza, Hynek Mergental, Ricky H. Bhogal, Simon C. Afford – 28 February 2019 – Strategies to increase the use of steatotic donor livers are required to tackle the mortality on the transplant waiting list. We aimed to test the efficacy of pharmacological enhancement of the lipid metabolism of human livers during ex situ normothermic machine perfusion to promote defatting and improve the functional recovery of the organs.

The “Skinny” on Assessment and Utilization of Steatotic Liver Grafts: A Systematic Review

Kristopher P. Croome, David D. Lee, C. Burcin Taner – 28 February 2019 – The frequency at which steatotic deceased donor liver grafts are encountered will likely continue to increase. Utilization of liver grafts with moderate‐to‐severe steatosis for liver transplantation (LT) has been previously shown to be associated with increased rates of primary nonfunction and decreased recipient survival. In order to better inform clinical decision making and guide future research, critical evaluation of the literature on donor liver steatosis and posttransplantation outcome is needed.

Subscribe to