Are There Upper Limits in Tumor Burden for Down‐Staging of Hepatocellular Carcinoma to Liver Transplant? Analysis of the All‐Comers Protocol

Jasmine Sinha, Neil Mehta, Jennifer L. Dodge, Eduard Poltavskiy, John Roberts, Francis Yao – 19 February 2019 – Patients with hepatocellular carcinoma (HCC) within the University of California, San Francisco down‐staging (UCSF‐DS) criteria (one lesion > 5 cm and ≤ 8 cm; two to three lesions each ≤ 5 cm; or four to five lesions each ≤ 3 cm with total tumor diameter ≤ 8 cm) who achieved successful down‐staging (DS) to Milan criteria had similar outcomes after liver transplantation (LT) compared with HCC initially meeting the Milan criteria.

Ex Vivo Hepatocyte Reprograming Promotes Homology‐Directed DNA Repair to Correct Metabolic Disease in Mice After Transplantation

Caitlin J. VanLith, Rebekah M. Guthman, Clara T. Nicolas, Kari L. Allen, Yuanhang Liu, Jennifer A. Chilton, Zachariah P. Tritz, Scott L. Nyberg, Robert A. Kaiser, Joseph B. Lillegard, Raymond D. Hickey – 15 February 2019 – Ex vivo CRISPR/Cas9‐mediated gene editing in hepatocytes using homology‐directed repair (HDR) is a potential alternative curative therapy to organ transplantation for metabolic liver disease.

Application of 3‐Dimensional Printing in Pediatric Living Donor Liver Transplantation: A Single‐Center Experience

Pusen Wang, Weitao Que, Mingman Zhang, Xiaoke Dai, Kanru Yu, Chunguang Wang, Zhihai Peng, Lin Zhong – 15 February 2019 – Three‐dimensional (3D) printing has been used to support organ transplantations. However, whether it helps remains unclear. This study aimed to present and assess the application of 3D‐printed liver models in pediatric living donor liver transplantation (LDLT). The 3D images were printed to touchable liver models with transparent liver parenchyma, specifically colored hepatic vessels, and biliary structures.

The Yield and Safety of Screening Colonoscopy in Patients Evaluated for Liver Transplantation

Rosalie C. Oey, Laurelle van Tilburg, Nicole S. Erler, Herold J. Metselaar, Manon C.W. Spaander, Henk R. van Buuren, Robert A. de Man – 14 February 2019 – Colorectal cancer (CRC) screening with colonoscopy is commonly used in patients who are candidates for liver transplantation. We initiated this study to define the risk‐benefit ratio of performing screening colonoscopy in this population. A retrospective observational study of all consecutive patients undergoing colonoscopy during pre–liver transplantation screening between 2004 and 2017 was conducted.

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