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Sumeet K. Asrani, Jeanette Hasse – 24 December 2018
Low Serum Hepcidin Is Associated With Reduced Short‐Term Survival in Adults With Acute Liver Failure
Igor Spivak, Jyoti Arora, Caitlyn Meinzer, Valerie Durkalski‐Mauldin, William M. Lee, Christian Trautwein, Robert J. Fontana, Pavel Strnad, for the Acute Liver Failure Study Group (ALFSG) – 24 December 2018 – The liver has an important role in iron homeostasis through the synthesis of the serum transporter transferrin and the iron hormone hepcidin. The aim of this study was to analyze parameters of iron metabolism in a multicenter cohort of adult patients with acute liver failure (ALF) and in an acetaminophen (APAP)‐induced ALF mouse model.
The Role of Three‐Dimensional Magnetic Resonance Elastography in the Diagnosis of Nonalcoholic Steatohepatitis in Obese Patients Undergoing Bariatric Surgery
Alina M. Allen, Vijay H. Shah, Terry M. Therneau, Sudhakar K. Venkatesh, Taofic Mounajjed, Joseph J. Larson, Kristin C. Mara, Phillip J. Schulte, Todd A. Kellogg, Michael L. Kendrick, Travis J. McKenzie, Suzanne M. Greiner, Jiahui Li, Kevin J. Glaser, Michael L. Wells, Jun Chen, Richard L. Ehman, Meng Yin – 24 December 2018 – The lack of reliable, noninvasive methods to diagnose early nonalcoholic steatohepatitis (NASH) is a major unmet need.
Tremelimumab in Combination With Microwave Ablation in Patients With Refractory Biliary Tract Cancer
Changqing Xie, Austin G. Duffy, Donna Mabry‐Hrones, Bradford Wood, Elliot Levy, Venkatesh Krishnasamy, Javed Khan, Jun S. Wei, David Agdashian, Manoj Tyagi, Vineela Gangalapudi, Suzanne Fioravanti, Melissa Walker, Victoria Anderson, David Venzon, William D. Figg, Milan Sandhu, David E. Kleiner, Maria Pia Morelli, Charalampos S. Floudas, Gagandeep Brar, Seth M. Steinberg, Firouzeh Korangy, Tim F. Greten – 22 December 2018 – Treatment options for patients with advanced biliary tract cancer are limited.
Infigratinib Mediates Vascular Normalization, Impairs Metastasis, and Improves Chemotherapy in Hepatocellular Carcinoma
Hung Huynh, Liek Yeow Lee, Kah Yong Goh, Richard Ong, Huai‐Xiang Hao, Alan Huang, Youzhen Wang, Diana Graus Porta, Pierce Chow, Alexander Chung – 21 December 2018 – The fibroblast growth factor (FGF) signaling cascade is a key signaling pathway in hepatocarcinogenesis. We report high FGF receptor (FGFR) expression in 17.7% (11 of 62) of hepatocellular carcinoma (HCC) models. Infigratinib, a pan‐FGFR inhibitor, potently suppresses the growth of high‐FGFR‐expressing and sorafenib‐resistant HCCs.
Should LR‐M and LR‐TIV Remain Separate Categories in LI‐RADS?
Myeong‐Jin Kim, Sunyoung Lee – 21 December 2018
The Triumph of Bacchus: The Emergence of Nonalcoholic Steatohepatitis and Alcoholic Liver Disease as the Leading Causes of Mortality From Cirrhosis
Thomas G. Cotter, Michael R. Charlton – 20 December 2018
Acute Hepatic Porphyrias: Review and Recent Progress
Bruce Wang, Sean Rudnick, Brent Cengia, Herbert L. Bonkovsky – 20 December 2018 – The acute hepatic porphyrias (AHPs) are a group of four inherited diseases of heme biosynthesis that present with episodic, acute neurovisceral symptoms. The four types are 5‐aminolevulinic acid (ALA) dehydratase deficiency porphyria, acute intermittent porphyria, hereditary coproporphyria, and variegate porphyria. Their diagnoses are often missed or delayed because the clinical symptoms mimic other more common disorders.
Factors Associated With Outcomes of Patients With Primary Sclerosing Cholangitis and Development and Validation of a Risk Scoring System
Elizabeth C. Goode, Allan B. Clark, George F. Mells, Brijesh Srivastava, Kelly Spiess, William T.H. Gelson, Palak J. Trivedi, Kate D. Lynch, Edit Castren, Mette N. Vesterhus, Tom H. Karlsen, Sun‐Gou Ji, Carl A. Anderson, Douglas Thorburn, Mark Hudson, Michael A. Heneghan, Mark A. Aldersley, Andrew Bathgate, Richard N. Sandford, Graeme J. Alexander, Roger W. Chapman, Martine Walmsley, UK‐PSC Consortium, Gideon M. Hirschfield, Simon M.
Human Immunodeficiency Virus/Hepatitis C Virus (HCV) Co‐infected Patients With Cirrhosis Are No Longer at Higher Risk for Hepatocellular Carcinoma or End‐Stage Liver Disease as Compared to HCV Mono‐infected Patients
Dominique Salmon‐Ceron, Pierre Nahon, Richard Layese, Valérie Bourcier, Philippe Sogni, Firouze Bani‐Sadr, Etienne Audureau, Laurence Merchadou, François Dabis, Linda Wittkop, Françoise Roudot‐Thoraval, for the ANRS CO12 CirVir and ANRS CO13 HEPAVIH study groups – 19 December 2018 – It is widely accepted that human immunodeficiency virus (HIV) infection is a risk factor for increased severity of hepatitis C virus (HCV) liver disease.