Loren Laine – 18 December 2018

Jie Wu, Yuqing Zhou, Xiaofang Fu, Min Deng, Yang Zheng, Guo Tian, Yiping Li, Chencheng Wang, Cheng Ding, Bing Ruan, Shigui Yang, Lanjuan Li – 18 December 2018 – The launch of new direct‐acting antivirals (DAAs) is expected to substantially reduce the burden of hepatitis C virus (HCV) in China. However, the effect of these changes has not yet been modeled in China. Therefore, we aim to predict the burden of HCV‐related diseases in China by simulating different scenarios that incorporate recent therapeutic advances of HCV and China’s current screening strategy.

Beatriz Aguilar‐Bravo, Daniel Rodrigo‐Torres, Silvia Ariño, Mar Coll, Elisa Pose, Delia Blaya, Isabel Graupera, Luis Perea, Júlia Vallverdú, Teresa Rubio‐Tomás, Laurent Dubuquoy, Carolina Armengol, Antonio Lo Nigro, Peter Stärkel, Philippe Mathurin, Ramon Bataller, Joan Caballería, Juan José Lozano, Pere Ginès, Pau Sancho‐Bru – 18 December 2018 – Chronic liver diseases are characterized by the expansion of ductular reaction (DR) cells and the expression of liver progenitor cell (LPC) markers.

Mar Riveiro‐Barciela, Merche Gironella, Alicia Senín, María‐Teresa Salcedo, Xavier Merino‐Casabiel, Lluis Castells, Rafael Esteban, Maria Buti, Fernando Martínez‐Valle – 18 December 2018

Jiaye Liu, Tao Li, Li Zhang, Aiqiang Xu – 18 December 2018 – In actual clinical practice, infinite nucleos(t)ide analogues (NAs) treatment for chronic hepatitis B virus (HBV) infection is unrealistic. The most commonly used endpoint is suppression of HBV DNA to undetectable levels with normalization of alanine aminotransferase. However, this criterion for cessation of treatment is associated with various incidences of virological and clinical relapse.

Samer Chehade, Paul C. Adams – 18 December 2018

Katalina Funke, Don C. Rockey – 18 December 2018

Carol J. Soroka, David N. Assis, Leina S. Alrabadi, Scott Roberts, Laura Cusack, Ariel B. Jaffe, James L. Boyer – 18 December 2018 – Primary sclerosing cholangitis (PSC) is a heterogeneous and progressive fibroinflammatory cholangiopathy with no known etiology or effective treatment. Studies of PSC are limited due to difficulty in accessing the cholangiocyte, the small percentage of these cells in the liver, instability of in vitro culture systems, and reliance on samples from end‐stage disease.

Xueliang Zuo, Zhiqiang Chen, Juan Cai, Wen Gao, Yao Zhang, Guoyong Han, Liyong Pu, Zhengshan Wu, Wei You, Jianjie Qin, Xinzheng Dai, Hongbing Shen, Jindao Wu, Xuehao Wang – 18 December 2018 – Serotonin and its receptors have been shown to play critical regulatory roles in cancer biology. Nevertheless, the contributions of 5‐hydroxytryptamine 1D (5‐HT1D), an indispensable member of the serotonergic system, to hepatocellular carcinoma (HCC) remain unknown. The present study demonstrated that the 5‐HT1D expression level was significantly up‐regulated in HCC tissues and cell lines.

Luca Maroni, Claudio Pinto, Debora Maria Giordano, Stefania Saccomanno, Jesus M. Banales, Daniele Spallacci, Maria Cristina Albertini, Fiorenza Orlando, Mauro Provinciali, Malgorzata Milkiewicz, Espen Melum, Ibone Labiano, Piotr Milkiewicz, Chiara Rychlicki, Luciano Trozzi, Marina Scarpelli, Antonio Benedetti, Gianluca Svegliati Baroni, Marco Marzioni – 18 December 2018 – Disorders of the biliary tree develop and progress differently according to patient age. It is currently not known whether the aging process affects the response to injury of cholangiocytes.