Eunkyong Ko, Hyun‐Wook Seo, Eun Sun Jung, Soomi Ju, Baek‐hui Kim, Hyeki Cho, Yoon Jun Kim, Young Min Park, Jong‐Seo Kim, Guhung Jung – 9 October 2018 – Class I phosphoinositide 3‐kinase (PI3K) signaling is a major pathway in human cancer development and progression. Among the four PI3K isoforms, PI3Kα and PI3Kβ are ubiquitously expressed, whereas PI3Kγ and PI3Kδ are found primarily in leukocytes. Until now, PI3K targeting in solid tumors has focused on inhibiting PI3Kα‐mediated and PI3Kβ‐mediated cancer cell–intrinsic PI3K activity. The role of PI3Kδ in solid tumors is unknown.

Axelle Cooreman, Raf Van Campenhout, Steven Ballet, Pieter Annaert, Bert Van Den Bossche, Isabelle Colle, Bruno Cogliati, Mathieu Vinken – 9 October 2018 – Connexin proteins are the building blocks of hemichannels, which dock further between adjacent cells to form gap junctions. Gap junctions control the intercellular exchange of critical homeostasis regulators. By doing so, gap junctions control virtually all aspects of the hepatic life cycle.

Adrian P. Mansini, Estanislao Peixoto, Sujeong Jin, Seth Richard, Sergio A. Gradilone – 9 October 2018 – Cholangiocytes, the epithelial cells lining the biliary tree in the liver, express primary cilia that can detect several kinds of environmental signals and then transmit this information into the cell. We have reported that cilia are significantly reduced in cholangiocarcinoma (CCA) and that the experimental deciliation of normal cells induces a malignant‐like phenotype with increased proliferation, anchorage‐independent growth, invasion, and migration.

Axelle Cooreman, Raf Van Campenhout, Steven Ballet, Pieter Annaert, Bert Van Den Bossche, Isabelle Colle, Bruno Cogliati, Mathieu Vinken – 9 October 2018 – Connexin proteins are the building blocks of hemichannels, which dock further between adjacent cells to form gap junctions. Gap junctions control the intercellular exchange of critical homeostasis regulators. By doing so, gap junctions control virtually all aspects of the hepatic life cycle.

Maria J. Perugorria, Paula Olaizola, Jesus M. Banales – 8 October 2018

Nila J. Dharan, Jacqueline Neuhaus, Juergen K. Rockstroh, Lars Peters, Fred Gordin, Alejandro Arenas‐Pinto, Carol Emerson, Kristen Marks, Jose Hidalgo, Rui Sarmento‐Castro, Christoph Stephan, Nagalingeswaran Kumarasamy, Sean Emery, Gail V. Matthews, for the INSIGHT START Study Group – 8 October 2018 – The role of antiretroviral therapy (ART) in reducing or contributing to liver fibrosis in persons with human immunodeficiency virus (HIV) is unclear.

Giorgio A. Roccaro, Robert Mitrani, Wei‐Ting Hwang, Kimberly A. Forde, K. Rajender Reddy – 6 October 2018 – Posttransplant diabetes mellitus (PTDM), an increasingly recognized complication of solid organ transplantation, is associated with increased morbidity and mortality following liver transplantation (LT). Hepatitis C virus (HCV) infection is a consistent and modifiable risk factor for PTDM. Prior studies have demonstrated improvement in glucose metabolism following sustained virological response (SVR).

5 October 2018

5 October 2018

Silvia Nardelli, Stefania Gioia, Lorenzo Ridola, Alessio Farcomeni, Manuela Merli, Oliviero Riggio – 5 October 2018 – Minimal hepatic encephalopathy (MHE) is a subclinical cognitive impairment frequently observable in patients with cirrhosis. Proton pump inhibitors (PPIs) can contribute to small‐bowel bacterial overgrowth, but no study has investigated the link between PPIs and MHE. We investigated the relationship between MHE and PPI use as well as the role of PPI use in the development of overt HE and survival.