Inhibition of Triggering Receptor Expressed on Myeloid Cells 1 Ameliorates Inflammation and Macrophage and Neutrophil Activation in Alcoholic Liver Disease in Mice

David Tornai, Istvan Furi, Zu T. Shen, Alexander B. Sigalov, Sahin Coban, Gyongyi Szabo – 29 October 2018 – Alcoholic liver disease (ALD) is characterized by macrophage and neutrophil leukocyte recruitment and activation in the liver. Damage‐ and pathogen‐associated molecular patterns contribute to a self‐perpetuating proinflammatory state in ALD. Triggering receptor expressed on myeloid cells 1 (TREM‐1) is a surface receptor that amplifies inflammation induced by toll‐like receptors (TLRs) and is expressed on neutrophils and monocytes/macrophages.

Obeticholic Acid Modulates Serum Metabolites and Gene Signatures Characteristic of Human NASH and Attenuates Inflammation and Fibrosis Progression in Ldlr‐/‐.Leiden Mice

Martine C. Morrison, Lars Verschuren, Kanita Salic, Joanne Verheij, Aswin Menke, Peter Y. Wielinga, Marta Iruarrizaga‐Lejarreta, Laurent Gole, Wei‐Miao Yu, Scott Turner, Martien P.M. Caspers, Ibon Martínez‐Arranz, Elsbet Pieterman, Reinout Stoop, Arianne van Koppen, Anita M. van den Hoek, José M.

Mouse Models of Nonalcoholic Steatohepatitis: Toward Optimization of Their Relevance to Human Nonalcoholic Steatohepatitis

Geoff Farrell, Jörn M. Schattenberg, Isabelle Leclercq, Matthew M. Yeh, Robert Goldin, Narci Teoh, Detlef Schuppan – 29 October 2018 – Nonalcoholic steatohepatitis (NASH) arises from a variable interplay between environmental factors and genetic determinants that cannot be completely replicated in animals. Notwithstanding, preclinical models are needed to understand NASH pathophysiology and test mechanism‐based therapies.

Association of Pretransplant Renal Function With Liver Graft and Patient Survival After Liver Transplantation in Patients With Nonalcoholic Steatohepatitis

Miklos Z. Molnar, Kiran Joglekar, Yu Jiang, George Cholankeril, Mubeen Khan Mohammed Abdul, Satish Kedia, Humberto C. Gonzalez, Aijaz Ahmed, Ashwani Singal, Kalyan Ram Bhamidimarri, Guruprasad Padur Aithal, Ajay Duseja, Vincent Wai‐Sun Wong, Agayeva Gulnare, Puneet Puri, Satheesh Nair, James D. Eason, Sanjaya K. Satapathy, the Global NAFLD Consortium – 28 October 2018 – Nonalcoholic steatohepatitis (NASH) is one of the top 3 indications for liver transplantation (LT) in Western countries.

Impact of Prior Bariatric Surgery on Perioperative Liver Transplant Outcomes

Rajab Idriss, Jeanette Hasse, Tiffany Wu, Fatima Khan, Giovanna Saracino, Greg McKenna, Giuliano Testa, James Trotter, Goran Klintmalm, Sumeet K. Asrani – 28 October 2018 – Bariatric surgery (BS) is effective in treating morbid obesity, but the impact of prior BS on candidacy for liver transplantation (LT) is unclear. We examined 78 patients with cirrhosis with prior BS compared with a concurrent cohort of 156 patients matched by age, Model for End‐Stage Liver Disease score, and underlying liver disease.

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