Reducing Cell‐Free DNA and Neutrophil Extracellular Traps May Improve Outcomes of Orthotopic Liver Transplantation
Danielle H. Moore, Neeral L. Shah – 29 October 2018
Obeticholic Acid Modulates Serum Metabolites and Gene Signatures Characteristic of Human NASH and Attenuates Inflammation and Fibrosis Progression in Ldlr‐/‐.Leiden Mice
Martine C. Morrison, Lars Verschuren, Kanita Salic, Joanne Verheij, Aswin Menke, Peter Y. Wielinga, Marta Iruarrizaga‐Lejarreta, Laurent Gole, Wei‐Miao Yu, Scott Turner, Martien P.M. Caspers, Ibon Martínez‐Arranz, Elsbet Pieterman, Reinout Stoop, Arianne van Koppen, Anita M. van den Hoek, José M.
Inhibition of Triggering Receptor Expressed on Myeloid Cells 1 Ameliorates Inflammation and Macrophage and Neutrophil Activation in Alcoholic Liver Disease in Mice
David Tornai, Istvan Furi, Zu T. Shen, Alexander B. Sigalov, Sahin Coban, Gyongyi Szabo – 29 October 2018 – Alcoholic liver disease (ALD) is characterized by macrophage and neutrophil leukocyte recruitment and activation in the liver. Damage‐ and pathogen‐associated molecular patterns contribute to a self‐perpetuating proinflammatory state in ALD. Triggering receptor expressed on myeloid cells 1 (TREM‐1) is a surface receptor that amplifies inflammation induced by toll‐like receptors (TLRs) and is expressed on neutrophils and monocytes/macrophages.
Mouse Models of Nonalcoholic Steatohepatitis: Toward Optimization of Their Relevance to Human Nonalcoholic Steatohepatitis
Geoff Farrell, Jörn M. Schattenberg, Isabelle Leclercq, Matthew M. Yeh, Robert Goldin, Narci Teoh, Detlef Schuppan – 29 October 2018 – Nonalcoholic steatohepatitis (NASH) arises from a variable interplay between environmental factors and genetic determinants that cannot be completely replicated in animals. Notwithstanding, preclinical models are needed to understand NASH pathophysiology and test mechanism‐based therapies.
Combined Hypothermic and Normothermic Perfusion for the Optimization of Injured Liver Grafts
Cristiano Quintini, Laura Lomaglio, Daniele Pezzati, Teresa Diago Uso, Qiang Liu – 29 October 2018
Obeticholic Acid Modulates Serum Metabolites and Gene Signatures Characteristic of Human NASH and Attenuates Inflammation and Fibrosis Progression in Ldlr‐/‐.Leiden Mice
Martine C. Morrison, Lars Verschuren, Kanita Salic, Joanne Verheij, Aswin Menke, Peter Y. Wielinga, Marta Iruarrizaga‐Lejarreta, Laurent Gole, Wei‐Miao Yu, Scott Turner, Martien P.M. Caspers, Ibon Martínez‐Arranz, Elsbet Pieterman, Reinout Stoop, Arianne van Koppen, Anita M. van den Hoek, José M.
DNAX Activating Protein of 12 kDa/Triggering Receptor Expressed on Myeloid Cells 2 Expression by Mouse and Human Liver Dendritic Cells: Functional Implications and Regulation of Liver Ischemia–Reperfusion Injury
Toshimasa Nakao, Yoshihiro Ono, Helong Dai, Ryosuke Nakano, Angelica Perez‐Gutierrez, Geoffrey Camirand, Hai Huang, David A. Geller, Angus W. Thomson – 29 October 2018 – Liver interstitial dendritic cells (DCs) have been implicated in the control of ischemia–reperfusion injury (IRI) and host immune responses following liver transplantation. Mechanisms underlying these regulatory functions of hepatic DCs remain unclear.
Timely Administration of Birth Dose Hepatitis B Virus Vaccine May Break the Chain of Perinatal Transmission
Aysha Aslam, Rizwan Ishtiaq, Dary T.Y. Lau – 29 October 2018
Combined Hepatocellular–Cholangiocarcinoma in a Patient With Cirrhosis Due to Cholesteryl Ester Storage Disease
Graciela Elia Castro Narro, Armando Gamboa Domínguez, Alejandra Consuelo Sánchez, Abel Salazar Martínez, Jose Agramonte Hevia, J.J. Cebolla, Miguel Enrique Cuellar Mendoza, Héctor Adrián Díaz Hernández – 29 October 2018
Impact of Prior Bariatric Surgery on Perioperative Liver Transplant Outcomes
Rajab Idriss, Jeanette Hasse, Tiffany Wu, Fatima Khan, Giovanna Saracino, Greg McKenna, Giuliano Testa, James Trotter, Goran Klintmalm, Sumeet K. Asrani – 28 October 2018 – Bariatric surgery (BS) is effective in treating morbid obesity, but the impact of prior BS on candidacy for liver transplantation (LT) is unclear. We examined 78 patients with cirrhosis with prior BS compared with a concurrent cohort of 156 patients matched by age, Model for End‐Stage Liver Disease score, and underlying liver disease.