Hepatology Highlights

Norihiro Imai, Tibor I. Krisko, Zaid H. Tafesh, Catherine Lucero, Michele Alves‐Bezerra, Hayley T. Nicholls, Sandra Steensels, Baran A. Ersoy, Russell Rosenblatt, Robert E. Schwartz, Vikas Gupta, Zurabi Lominadze, Brett E. Fortune – 27 October 2018

PAPD5/7 Are Host Factors That Are Required for Hepatitis B Virus RNA Stabilization

Henrik Mueller, Anaïs Lopez, Philipp Tropberger, Steffen Wildum, Josephine Schmaler, Lykke Pedersen, Xingchun Han, Yongguang Wang, Søren Ottosen, Song Yang, John A.T. Young, Hassan Javanbakht – 26 October 2018 – RG7834 is a potent, orally bioavailable small‐molecule inhibitor of hepatitis B virus (HBV) gene expression that belongs to the dihydroquinolizinone (DHQ) chemical class and uniquely blocks production of both viral DNA and antigens.

Pilot, Open, Randomized, Prospective Trial for Normothermic Machine Perfusion Evaluation in Liver Transplantation From Older Donors

Davide Ghinolfi, Erion Rreka, Vincenzo De Tata, Maria Franzini, Daniele Pezzati, Vanna Fierabracci, Matilde Masini, Andrea Cacciatoinsilla, Maria Lucia Bindi, Lorella Marselli, Valentina Mazzotti, Riccardo Morganti, Piero Marchetti, Giandomenico Biancofiore, Daniela Campani, Aldo Paolicchi, Paolo De Simone – 26 October 2018 – Ex situ normothermic machine perfusion (NMP) might minimize ischemia/reperfusion injury (IRI) of liver grafts. In this study, 20 primary liver transplantation recipients of older grafts (≥70 years) were randomized 1:1 to NMP or cold storage (CS) groups.

Magnetic Resonance Imaging Is Cost‐Effective for Hepatocellular Carcinoma Surveillance in High‐Risk Patients With Cirrhosis

Hye‐Lin Kim, Jihyun An, Jae‐A Park, Seung‐Hoo Park, Young‐Suk Lim, Eui‐Kyung Lee – 26 October 2018 – Ultrasonography (US) is generally recommended for the surveillance of hepatocellular carcinoma (HCC) in patients at risk. However, in patients with cirrhosis who have sufficiently high HCC incidence, surveillance using magnetic resonance imaging (MRI) with liver‐specific contrast showed markedly higher sensitivity in detecting early‐stage HCC than US.

Readdressing the Middle Hepatic Vein in Right Lobe Liver Donation: Triangle of Safety

Sanjay Goja, Sanjay Kumar Yadav, Arvinder Singh Soin – 25 October 2018 – For equipoising donor safety and optimal recipient outcomes, we adopted an algorithmic “triangle of safety” approach to retrieve 3 types of right lobe liver grafts (RLGs), namely, the modified extended right lobe graft (MERLG), the partial right lobe graft (PRLG), and the modified right lobe graft (MRLG). Reconstruction to achieve a single wide anterior sector outflow was ensured in all patients.

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