Living Donor Liver Transplantation for Acute‐on‐Chronic Liver Failure

Sanjay Kumar Yadav, Neeraj Saraf, Narendra S. Choudhary, Jayant Kumar Sah, Sujeet Kumar Sah, Amit Rastogi, Prashant Bhangui, Sanjiv Saigal, Arvinder Singh Soin – 8 December 2018 – Acute‐on‐chronic liver failure (ACLF) is a syndrome characterized by acute decompensation of previously diagnosed or undiagnosed liver disease with organ failure(s) with high short‐term mortality. This study was conducted to report the outcomes of living donor liver transplantation (LDLT) in ACLF and assess the survival benefit of liver transplantation (LT) in these patients.

Fibrinolysis Shutdown Is Associated With Thrombotic and Hemorrhagic Complications and Poorer Outcomes After Liver Transplantation

Ramona Nicolau‐Raducu, Thiago Beduschi, Rodrigo Vianna, Christian Diez, Mahmoud Sleem, Bhavna P. Singh, Georgia Vasileiou, Yehuda Raveh – 7 December 2018 – Detrimental consequences of hypofibrinolysis, also known as fibrinolysis shutdown (FS), have recently arisen, and its significance in liver transplantation (LT) remains unknown. To fill this gap, this retrospective study included 166 adults who received transplants between 2016 and 2018 for whom baseline thromboelastography was available.

Orchestration of Tryptophan‐Kynurenine Pathway, Acute Decompensation, and Acute‐on‐Chronic Liver Failure in Cirrhosis

Joan Clària, Richard Moreau, François Fenaille, Alex Amorós, Christophe Junot, Henning Gronbaek, Minneke J. Coenraad, Alain Pruvost, Aurélie Ghettas, Emeline Chu‐Van, Cristina López‐Vicario, Karl Oettl, Paolo Caraceni, Carlo Alessandria, Jonel Trebicka, Marco Pavesi, Carme Deulofeu, Agustin Albillos, Thierry Gustot, Tania M. Welzel, Javier Fernández, Rudolf E.

Stereotactic Radiofrequency Ablation of Hepatocellular Carcinoma: a Histopathological Study in Explanted Livers

Reto Bale, Peter Schullian, Gernot Eberle, Daniel Putzer, Heinz Zoller, Stefan Schneeberger, Claudia Manzl, Patrizia Moser, Georg Oberhuber – 5 December 2018 – This retrospective study was performed to evaluate the efficacy of three‐dimensional (3D)‐navigated multiprobe radiofrequency ablation (RFA) with intraprocedural image fusion for treatment of hepatocellular carcinoma (HCC) by histopathological examination. From 2009 to 2018, 97 patients (84 men, 13 women; median age, 60 years; range, 1‐71) were transplanted after bridging therapy of 195 HCCs by stereotactic RFA (SRFA).

Stereotactic Radiofrequency Ablation of Hepatocellular Carcinoma: a Histopathological Study in Explanted Livers

Reto Bale, Peter Schullian, Gernot Eberle, Daniel Putzer, Heinz Zoller, Stefan Schneeberger, Claudia Manzl, Patrizia Moser, Georg Oberhuber – 5 December 2018 – This retrospective study was performed to evaluate the efficacy of three‐dimensional (3D)‐navigated multiprobe radiofrequency ablation (RFA) with intraprocedural image fusion for treatment of hepatocellular carcinoma (HCC) by histopathological examination. From 2009 to 2018, 97 patients (84 men, 13 women; median age, 60 years; range, 1‐71) were transplanted after bridging therapy of 195 HCCs by stereotactic RFA (SRFA).

Hepatic Autophagy Deficiency Compromises Farnesoid X Receptor Functionality and Causes Cholestatic Injury

Bilon Khambu, Tiangang Li, Shengmin Yan, Changshun Yu, Xiaoyun Chen, Michael Goheen, Yong Li, Jingmei Lin, Oscar W. Cummings, Youngmin A. Lee, Scott Friedman, Zheng Dong, Gen‐Sheng Feng, Shangwei Wu, Xiao‐Ming Yin – 5 December 2018 – Autophagy is important for hepatic homeostasis, nutrient regeneration, and organelle quality control. We investigated the mechanisms by which liver injury occurred in the absence of autophagy function.

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