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Human CD96 Correlates to Natural Killer Cell Exhaustion and Predicts the Prognosis of Human Hepatocellular Carcinoma

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Haoyu Sun, Qiang Huang, Mei Huang, Hao Wen, Renyong Lin, Meijuan Zheng, Kun Qu, Kun Li, Haiming Wei, Weihua Xiao, Rui Sun, Zhigang Tian, Cheng Sun – 8 November 2018 – Immune checkpoint blockade has become a promising therapeutic approach to reverse immune cell exhaustion. Coinhibitory CD96 and T‐cell immunoglobulin and ITIM domain (TIGIT), together with costimulatory CD226, bind to common ligand CD155. The balancing between three receptors fine‐tunes immune responses against tumors.

Issue Information

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8 November 2018

Issue Information ‐ Author Checklist

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8 November 2018

Pro: Use of Hepatitis C Virus–Positive Donors Should Be Considered Standard of Care

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William A. Werbel, Christine M. Durand – 6 November 2018

Spotlight on Impactful Research: Evaluation of Hepatitis B Reactivation Among 62,920 Veterans Treated With Oral Hepatitis C Antivirals

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Mina Rakoski – 6 November 2018

Misconception: You Can’t Have Liver Disease With Normal Liver Chemistries

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Zurabi Lominadze, Eric R. Kallwitz – 6 November 2018

Assessment and Management of Nutrition Status in the Hospitalized Patient With Cirrhosis

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Christopher Moore, Adam C. Stein – 6 November 2018

Con: Use of Hepatitis C Virus–Positive Donors Should Be Restricted to Research Protocols

Read more about Con: Use of Hepatitis C Virus–Positive Donors Should Be Restricted to Research Protocols

Grace S. Lee, Judith A. Anesi, Behdad D. Besharatian, Therese Bittermann, Stephanie Hamel, David S. Goldberg – 6 November 2018

At Diagnosis of Hepatocellular Carcinoma, African Americans With Hepatitis C Have Better Liver Function Than Other Patients

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Adam C. Winters, Julie C. Sung, Brooke Wyatt, Deeva Berera, Thomas D. Schiano, Myron E. Schwartz, Ponni V. Perumalswami, Andrea D. Branch – 6 November 2018

Estimating Prevalence of Hepatitis C Virus Infection in the United States, 2013‐2016

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Megan G. Hofmeister, Elizabeth M. Rosenthal, Laurie K. Barker, Eli S. Rosenberg, Meredith A. Barranco, Eric W. Hall, Brian R. Edlin, Jonathan Mermin, John W. Ward, A. Blythe Ryerson – 6 November 2018 – Hepatitis C virus (HCV) infection is the most commonly reported bloodborne infection in the United States, causing substantial morbidity and mortality and costing billions of dollars annually.

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