Down‐regulation of TROP‐2 Predicts Poor Prognosis of Hepatocellular Carcinoma Patients

Sarah T. K. Sin, Yan Li, Ming Liu, Yun‐Fei Yuan, Stephanie Ma, Xin‐Yuan Guan – 2 October 2018 – Hepatocellular carcinoma (HCC) is one of the most common and lethal cancer types worldwide, especially in Asian countries. Genetic alterations, including hyperactivation of oncogenes and loss of expression of tumor suppressor genes, greatly contribute to the initiation and progression of HCC. Here we report that down‐regulation of trophoblast cell surface antigen 2 (TROP‐2) was frequently detected in HCC.

Perinatal Nutritional Reprogramming of the Epigenome Promotes Subsequent Development of Nonalcoholic Steatohepatitis

Luz Helena Gutierrez Sanchez, Kyoko Tomita, Qianqian Guo, Kunimaro Furuta, Husam Alhuwaish, Petra Hirsova, Saurabh Baheti, Bonnie Alver, Ryan Hlady, Keith D. Robertson, Samar H. Ibrahim – 1 October 2018 – With the epidemic of obesity, nonalcoholic fatty liver disease (NAFLD) has become the most common pediatric liver disease. The influence of a perinatal obesity‐inducing diet (OID) on the development and progression of NAFLD in offspring is important but incompletely studied.

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