Onset of Donor Warm Ischemia Time in Donation After Circulatory Death Liver Transplantation: Hypotension or Hypoxia?

Marit Kalisvaart, Jubi E. Haan, Wojciech G. Polak, Jan N. M. IJzermans, Diederik Gommers, Herold J. Metselaar, Jeroen Jonge – 24 August 2018 – The aim of this study was to investigate the impact of hypoxia and hypotension during the agonal phase of donor warm ischemia time (DWIT) on hepatic ischemia/reperfusion injury (IRI) and complications in donation after circulatory death (DCD) liver transplantation. A retrospective single‐center study of 93 DCD liver transplants (Maastricht type III) was performed.

Class II Human Leukocyte Antigen Epitope Mismatch Predicts De Novo Donor‐Specific Antibody Formation After Liver Transplantation

Chandrashekhar A. Kubal, Richard Mangus, Burcin Ekser, Plamen Mihaylov, Brian Ceballos, Nancy Higgins, Naga Chalasani, Marwan Ghabril, Lauren Nephew, Andrew Lobashevsky – 24 August 2018 – Formation of de novo donor‐specific antibodies (dn‐DSAs) has been associated with longterm immunologic complications after liver transplantation (LT). We hypothesized that human leukocyte antigen (HLA) epitope/eplet mismatch (MM) is a marker of immunogenicity and a risk factor for dn‐DSA formation.

Management of Coagulation and Anticoagulation in Liver Transplantation Candidates

Patrick Northup, Bethany Reutemann – 24 August 2018 – Hemostasis is a complex balance of clot formation and dissolution that is largely modulated by protein synthesis and degradation in the liver. In the state of end‐stage liver disease, there is a disruption of the hemostatic system due to hepatic protein synthetic dysfunction. Because historical clinical laboratory testing often only analyzes a portion of the hemostasis system, the clinician may be misled into believing that cirrhosis patients are imbalanced with a tendency toward bleeding.

Abundance of Cytochromes in Hepatic Extracellular Vesicles Is Altered by Drugs Related With Drug‐Induced Liver Injury

Laura Palomo, Justyna Emilia Mleczko, Mikel Azkargorta, Javier Conde‐Vancells, Esperanza González, Felix Elortza, Félix Royo, Juan M. Falcon‐Perez – 23 August 2018 – Drug‐induced liver injury (DILI) is a serious worldwide health problem that accounts for more than 50% of acute liver failure. There is a great interest in clinical diagnosis and pharmaceutical industry to elucidate underlying molecular mechanisms and find noninvasive biomarkers for this pathology. Cell‐secreted extracellular vesicles (EVs) have provided a new biological source to identify low disease invasive markers.

Incomplete Differentiation of Engrafted Bone Marrow Endothelial Progenitor Cells Initiates Hepatic Fibrosis in the Rat

Ana C. Maretti‐Mira, Xiangdong Wang, Lei Wang, Laurie D. DeLeve – 23 August 2018 – Normal liver sinusoidal endothelial cells (LSECs) promote quiescence of hepatic stellate cells (HSCs). Prior to fibrosis, LSECs undergo capillarization, which is permissive for HSC activation, the proximate event in hepatic fibrosis. The aims of this study were to elucidate the nature of and mechanisms leading to capillarization and to determine how LSECs promote HSC quiescence and why “capillarized LSECs” lose control of HSC activation.

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