Lect2 Controls Inflammatory Monocytes to Constrain the Growth and Progression of Hepatocellular Carcinoma

Antoine L’Hermitte, Sandrine Pham, Mathilde Cadoux, Gabrielle Couchy, Stefano Caruso, Marie Anson, Anne‐Marie Crain‐Denoyelle, Séverine Celton‐Morizur, Satoshi Yamagoe, Jessica Zucman‐Rossi, Chantal Desdouets, Jean‐Pierre Couty – 2 August 2018 – Leukocyte cell‐derived chemotaxin‐2 (LECT2) was originally identified as a hepatocyte‐secreted chemokine‐like factor and a positive target of β‐catenin signaling. Here, we dissected out the mechanisms by which LECT2 modulates hepatocellular carcinoma (HCC) development using both HCC mouse models and human HCC samples.

Oxidized Albumin Triggers a Cytokine Storm in Leukocytes Through P38 Mitogen‐Activated Protein Kinase: Role in Systemic Inflammation in Decompensated Cirrhosis

José Alcaraz‐Quiles, Mireia Casulleras, Karl Oettl, Esther Titos, Roger Flores‐Costa, Marta Duran‐Güell, Cristina López‐Vicario, Marco Pavesi, Rudolf E. Stauber, Vicente Arroyo, Joan Clària – 2 August 2018 – Decompensated cirrhosis is characterized by exuberant systemic inflammation. Although the inducers of this feature remain unknown, the presence of circulating forms of oxidized albumin, namely human nonmercaptalbumin 1 (HNA1) and HNA2, is a common finding in cirrhosis.

Pulse Oximetry Is Insensitive for Detection of Hepatopulmonary Syndrome in Patients Evaluated for Liver Transplantation

Kimberly A. Forde, Michael B. Fallon, Michael J. Krowka, Michael Sprys, David S. Goldberg, Karen L. Krok, Mamta Patel, Grace Lin, Jae K. Oh, Carl D. Mottram, Paul D. Scanlon, Steven M. Kawut, for the Pulmonary Vascular Complications of Liver Disease 2 Study Group – 2 August 2018 – Screening for hepatopulmonary syndrome (HPS) using pulse oximetry is recommended in liver transplant (LT) candidates because mortality is increased, independently of the severity of the oxygenation defect. LT exception points may be afforded to those with HPS and severe hypoxemia.

Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region

Chiao‐Ling Li, Chen‐Yu Li, You‐Yu Lin, Ming‐Chih Ho, Ding‐Shinn Chen, Pei‐Jer Chen, Shiou‐Hwei Yeh – 2 August 2018 – The gender disparity of hepatocellular carcinoma (HCC) is most striking in hepatitis B virus (HBV)‐related cases. The majority of such HCC cases contain integrated HBV, and some hotspot integrations, such as those in the telomerase reverse transcriptase gene (TERT) promoter, activate gene expression to drive carcinogenesis.

Lactate Improves Prediction of Short‐Term Mortality in Critically Ill Patients With Cirrhosis: A Multinational Study

Andreas Drolz, Thomas Horvatits, Karoline Rutter, Felix Landahl, Kevin Roedl, Philippe Meersseman, Alexander Wilmer, Johannes Kluwe, Ansgar W. Lohse, Stefan Kluge, Michael Trauner, Valentin Fuhrmann – 2 August 2018 – Lactate levels and lactate clearance are known predictors of outcome in critically ill patients in the intensive care unit (ICU). The prognostic value of lactate is not well established in liver cirrhosis and acute‐on‐chronic liver failure (ACLF). The aim of this study was to assess the prognostic value of lactate levels and clearance in critically ill patients with cirrhosis.

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Norah A. Terrault, Robert S. Brown, Anna SF Lok, John B Wong, Natalie H Bzowej, Kyong‐Mi Chang, Jessica P Hwang, Maureen M Jonas, Brian J McMahon – 2 August 2018

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