Longitudinal Assessment of Three Serum Biomarkers to Detect Very Early‐Stage Hepatocellular Carcinoma

Jonggi Choi, Gi‐Ae Kim, Seungbong Han, Woochang Lee, Sail Chun, Young‐Suk Lim – 28 August 2018 – We aimed to determine the surveillance performance of alpha‐fetoprotein (AFP), lectin‐reactive AFP (AFP‐L3), des‐gamma‐carboxy prothrombin (DCP), and their combinations for the early detection of hepatocellular carcinoma (HCC) by using prospectively collected longitudinal samples in patients at risk.

Deficient Natural Killer Cell NKp30‐Mediated Function and Altered NCR3 Splice Variants in Hepatocellular Carcinoma

Stefania Mantovani, Barbara Oliviero, Andrea Lombardi, Stefania Varchetta, Dalila Mele, Angelo Sangiovanni, Giorgio Rossi, Matteo Donadon, Guido Torzilli, Cristiana Soldani, Camillo Porta, Paolo Pedrazzoli, Silvia Chiellino, Roberto Santambrogio, Enrico Opocher, Marcello Maestri, Stefano Bernuzzi, Armando Rossello, Sophie Clément, Claudio De Vito, Laura Rubbia‐Brandt, Francesco Negro, Mario U. Mondelli – 28 August 2018 – The activating natural cytotoxicity receptor NKp30 is critical for natural killer (NK) cell function and tumor immune surveillance.

Splenectomy as Flow Modulation Strategy and Risk Factors of De Novo Portal Vein Thrombosis in Adult‐to‐Adult Living Donor Liver Transplantation

Ivan Linares, Nicolas Goldaracena, Roizar Rosales, Luis De la Maza, Moritz Kaths, Dagmar Kollmann, Juan Echeverri, Nazia Selzner, Stuart A. McCluskey, Gonzalo Sapisochin, Leslie B. Lilly, Paul Greig, Mamatha Bhat, Anand Ghanekar, Mark Cattral, Ian McGilvray, David Grant, Markus Selzner – 26 August 2018 – Portal vein thrombosis (PVT) is a severe complication after liver transplantation that can result in increased morbidity and mortality. Few data are available regarding risk factors, classification, and treatment of PVT after living donor liver transplantation (LDLT).

Class II Human Leukocyte Antigen Epitope Mismatch Predicts De Novo Donor‐Specific Antibody Formation After Liver Transplantation

Chandrashekhar A. Kubal, Richard Mangus, Burcin Ekser, Plamen Mihaylov, Brian Ceballos, Nancy Higgins, Naga Chalasani, Marwan Ghabril, Lauren Nephew, Andrew Lobashevsky – 24 August 2018 – Formation of de novo donor‐specific antibodies (dn‐DSAs) has been associated with longterm immunologic complications after liver transplantation (LT). We hypothesized that human leukocyte antigen (HLA) epitope/eplet mismatch (MM) is a marker of immunogenicity and a risk factor for dn‐DSA formation.

Management of Coagulation and Anticoagulation in Liver Transplantation Candidates

Patrick Northup, Bethany Reutemann – 24 August 2018 – Hemostasis is a complex balance of clot formation and dissolution that is largely modulated by protein synthesis and degradation in the liver. In the state of end‐stage liver disease, there is a disruption of the hemostatic system due to hepatic protein synthetic dysfunction. Because historical clinical laboratory testing often only analyzes a portion of the hemostasis system, the clinician may be misled into believing that cirrhosis patients are imbalanced with a tendency toward bleeding.

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