Kaveh Hajifathalian, Babak Torabi Sagvand, Arthur J. McCullough – 19 August 2018 – Nonalcoholic fatty liver disease (NAFLD) comprises more than two thirds of patients with chronic liver disease in the United States. The effect of alcohol consumption on survival in patients with NAFLD is not clear. We gathered data on National Health and Nutrition Examination Survey participants from 1988 to 2010, and linked them to the National Death Index for follow‐up of their survival. We diagnosed NAFLD based on a previously validated biochemical model (Hepatic Steatosis Index).

Shanice A. Karangwa, Jelle Adelmeijer, Alix P. M. Matton, Vincent E. Meijer, Ton Lisman, Robert J. Porte – 19 August 2018

Mayank Sharma, Siddharth Singh, Vivek Desai, Vijay H. Shah, Patrick S. Kamath, Mohammad Hassan Murad, Douglas A. Simonetto – 19 August 2018 – We performed a systematic review with network meta‐analysis (NMA) to compare the efficacy of different approaches in primary prevention of esophageal variceal bleeding and overall survival in patients with cirrhosis with large varices. Thirty‐two randomized clinical trials (RCTs) with 3,362 adults with cirrhosis with large esophageal varices and no prior history of bleeding, with a minimum of 12 months of follow‐up, were included.

Slim Fourati, Christophe Rodriguez, Christophe Hézode, Alexandre Soulier, Isaac Ruiz, Lila Poiteau, Stéphane Chevaliez, Jean‐Michel Pawlotsky – 19 August 2018 – Hepatitis C virus (HCV) genotype 4 is highly heterogeneous. HCV subtype 4r has been suggested to be less responsive to direct‐acting antiviral (DAA) drug treatment than other genotype 4 subtypes.

Raluca Pais, Alban Redheuil, Philippe Cluzel, Vlad Ratziu, Philippe Giral – 19 August 2018 – Despite a well‐documented increase in the prevalence of subclinical atherosclerosis in patients with steatosis, the relationship among steatosis and atherosclerosis, specific atherosclerotic sites, multiple‐site atherosclerosis, and cardiovascular risk prediction is incompletely understood.

Anselm Wong, Richard McNulty, David Taylor, Marco Sivilotti, Shaun Greene, Naren Gunja, Zeff Koutsogiannis, Andis Graudins – 19 August 2018 – Historically, intravenous acetylcysteine has been delivered at a fixed dose and duration of 300 mg/kg over 20 to 21 hours to nearly every patient deemed to be at any risk for hepatotoxicity following acetaminophen overdose. We investigated a 12‐hour treatment regimen for selected low‐risk patients. This was a multicenter, open‐label, cluster‐controlled trial at six metropolitan emergency departments.

Raluca Pais, Alban Redheuil, Philippe Cluzel, Vlad Ratziu, Philippe Giral – 19 August 2018 – Despite a well‐documented increase in the prevalence of subclinical atherosclerosis in patients with steatosis, the relationship among steatosis and atherosclerosis, specific atherosclerotic sites, multiple‐site atherosclerosis, and cardiovascular risk prediction is incompletely understood.

Sungjin Ko, Satdarshan P. Monga – 18 August 2018

George B. McDonald, James W. Freston, James L. Boyer, Laurie D. DeLeve – 18 August 2018 – Treatment of hematological malignancy with antibody‐drug conjugates (ADCs) may cause liver injury. ADCs deliver a toxic moiety into antigen‐expressing tumor cells, but may also injure hepatic sinusoids (sinusoidal obstruction syndrome; SOS).

Fredrik Åberg, Helena Isoniemi, Eero Pukkala, Hannu Jalanko, Allan Rasmussen, Hans H. Storm, Nicolai Schultz, William Bennet, Nils Ekvall, Bo‐Göran Ericzon, Silvia Malenicka, Steinar Tretli, Pål‐Dag Line, Kirsten Muri Boberg, Anniken Østensen, Tom Hemming Karlsen, Arno Nordin – 18 August 2018 – Cancer after liver transplantation (LT) constitutes a threat also for young recipients, but cancer risk factors are usually absent in children and large studies on the cancer risk profile in young LT recipients are scarce.