Table of contents
5 July 2018
How to Deal With a Nonextractable Transjugular Intrahepatic Portosystemic Shunt Complicating Liver Transplantation
Nicholas Gilbo, Laurens J. Ceulemans, Geert Maleux, Frederik Nevens, Wim Laleman, Ina Jochmans, Diethard Monbaliu, Jacques Pirenne – 22 June 2018
Endothelial Wnts regulate β‐catenin signaling in murine liver zonation and regeneration: A sequel to the Wnt–Wnt situation
Morgan Preziosi, Hirohisa Okabe, Minakshi Poddar, Sucha Singh, Satdarshan P. Monga – 21 June 2018 – β‐Catenin in hepatocytes, under the control of Wnts, regulates pericentral gene expression. It also contributes to liver regeneration (LR) after partial hepatectomy (PH) by regulating cyclin‐D1 gene expression as shown in the β‐catenin and Wnt coreceptors low‐density lipoprotein receptor‐related protein 5/6 conditional knockouts (KO).
Endothelial Wnts regulate β‐catenin signaling in murine liver zonation and regeneration: A sequel to the Wnt–Wnt situation
Morgan Preziosi, Hirohisa Okabe, Minakshi Poddar, Sucha Singh, Satdarshan P. Monga – 21 June 2018 – β‐Catenin in hepatocytes, under the control of Wnts, regulates pericentral gene expression. It also contributes to liver regeneration (LR) after partial hepatectomy (PH) by regulating cyclin‐D1 gene expression as shown in the β‐catenin and Wnt coreceptors low‐density lipoprotein receptor‐related protein 5/6 conditional knockouts (KO).
Pro: Steroids Can Be Withdrawn After Transplant in Recipients With Autoimmune Hepatitis
Avash Kalra, James R. Burton, Lisa M. Forman – 19 June 2018 – Corticosteroids have been a mainstay of immunosuppression following liver transplantation. However, evolution in the field of transplant immunology has produced steroid‐free options, resulting in most transplant centers weaning steroids after transplant within days to months—an evidence‐based management decision. Patients with autoimmune hepatitis (AIH), however, receive corticosteroids prior to transplant. This raises the question of whether these patients should also be weaned from corticosteroids.
A Systematic Review and Meta‐Analysis of Cold In Situ Perfusion and Preservation of the Hepatic Allograft: Working Toward a Unified Approach
René Adam, Valérie Cailliez, Dorry L. Segev, Vincent Karam – 19 June 2018
The Genetic Architecture of Diet‐Induced Hepatic Fibrosis in Mice
Simon T. Hui, Zeyneb Kurt, Iina Tuominen, Frode Norheim, Richard C.Davis, Calvin Pan, Darwin L. Dirks, Clara E. Magyar, Samuel W. French, Karthickeyan Chella Krishnan, Simon Sabir, Francisco Campos‐Pérez, Nahum Méndez‐Sánchez, Luis Macías‐Kauffer, Paola León‐Mimila, Samuel Canizales‐Quinteros, Xia Yang, Simon W. Beaven, Adriana Huertas‐Vazquez, Aldons J. Lusis – 16 June 2018 – We report the genetic analysis of a “humanized” hyperlipidemic mouse model for progressive nonalcoholic steatohepatitis (NASH) and fibrosis.
The Genetic Architecture of Diet‐Induced Hepatic Fibrosis in Mice
Simon T. Hui, Zeyneb Kurt, Iina Tuominen, Frode Norheim, Richard C.Davis, Calvin Pan, Darwin L. Dirks, Clara E. Magyar, Samuel W. French, Karthickeyan Chella Krishnan, Simon Sabir, Francisco Campos‐Pérez, Nahum Méndez‐Sánchez, Luis Macías‐Kauffer, Paola León‐Mimila, Samuel Canizales‐Quinteros, Xia Yang, Simon W. Beaven, Adriana Huertas‐Vazquez, Aldons J. Lusis – 16 June 2018 – We report the genetic analysis of a “humanized” hyperlipidemic mouse model for progressive nonalcoholic steatohepatitis (NASH) and fibrosis.
Correspondence
Sadahisa Ogasawara, Tetsuhiro Chiba, Yoshihiko Ooka, Osamu Yokosuka, Naoya Kato – 14 June 2018
Nuclear receptors and liver disease: Summary of the 2017 basic research symposium
Melanie Tran, Yanjun Liu, Wendong Huang, Li Wang – 14 June 2018 – The nuclear receptor superfamily contains important transcriptional regulators that play pleiotropic roles in cell differentiation, development, proliferation, and metabolic processes to govern liver physiology and pathology. Many nuclear receptors are ligand‐activated transcription factors that regulate the expression of their target genes by modulating transcriptional activities and epigenetic changes.