Sanjay Kumar Yadav, Neeraj Saraf, Narendra S. Choudhary, Jayant Kumar Sah, Sujeet Kumar Sah, Amit Rastogi, Prashant Bhangui, Sanjiv Saigal, Arvinder Singh Soin – 8 December 2018 – Acute‐on‐chronic liver failure (ACLF) is a syndrome characterized by acute decompensation of previously diagnosed or undiagnosed liver disease with organ failure(s) with high short‐term mortality. This study was conducted to report the outcomes of living donor liver transplantation (LDLT) in ACLF and assess the survival benefit of liver transplantation (LT) in these patients.

Franziska Meister, Georg Lurje, Ulf Peter Neumann, Christian Trautwein, Pavel Strnad – 7 December 2018

Ramona Nicolau‐Raducu, Thiago Beduschi, Rodrigo Vianna, Christian Diez, Mahmoud Sleem, Bhavna P. Singh, Georgia Vasileiou, Yehuda Raveh – 7 December 2018 – Detrimental consequences of hypofibrinolysis, also known as fibrinolysis shutdown (FS), have recently arisen, and its significance in liver transplantation (LT) remains unknown. To fill this gap, this retrospective study included 166 adults who received transplants between 2016 and 2018 for whom baseline thromboelastography was available.

Joan Clària, Richard Moreau, François Fenaille, Alex Amorós, Christophe Junot, Henning Gronbaek, Minneke J. Coenraad, Alain Pruvost, Aurélie Ghettas, Emeline Chu‐Van, Cristina López‐Vicario, Karl Oettl, Paolo Caraceni, Carlo Alessandria, Jonel Trebicka, Marco Pavesi, Carme Deulofeu, Agustin Albillos, Thierry Gustot, Tania M. Welzel, Javier Fernández, Rudolf E.

Paulo S. Pinheiro – 6 December 2018

Lifeng Huang, Jie Cai, Han Guo, Jinyang Gu, Ying Tong, Bijun Qiu, Chenchen Wang, Meng Li, Lei Xia, Jianjun Zhang, Hailong Wu, Xiaoni Kong, Qiang Xia – 5 December 2018 – Cancer stem cells contribute to a high rate of recurrence and chemotherapeutic resistance in many types of cancer, including intrahepatic cholangiocarcinoma (ICC). Inhibitor of differentiation 3 (ID3) has been reported to promote cancer stem cells, but its role in ICC is obscure.

Douglas A. Simonetto, Laura Piccolo Serafim, Alice Gallo de Moraes, Ognjen Gajic, Patrick S. Kamath – 5 December 2018 – Sepsis in patients with cirrhosis is associated with high mortality. An impaired immune response accounts for the increased infection risk observed in these patients. Hemodynamic and systemic changes suggestive of sepsis may be observed in patients with cirrhosis in the absence of infection; therefore, diagnosis and treatment of sepsis may be delayed.

Cheuk‐Ting Law, Lai Wei, Felice Ho‐Ching Tsang, Cerise Yuen‐Ki Chan, Iris Ming‐Jing Xu, Robin Kit‐Ho Lai, Daniel Wai‐Hung Ho, Joyce Man‐Fong Lee, Carmen Chak‐Lui Wong, Irene Oi‐Lin Ng, Chun‐Ming Wong – 5 December 2018 – Hepatocellular carcinoma (HCC) is the third most lethal cancer worldwide. Increasing evidence shows that epigenetic alterations play an important role in human carcinogenesis. Deregulation of DNA methylation and histone modifications have recently been characterized in HCC, but the significance of chromatin remodeling in liver carcinogenesis remains to be explored.

Dun‐Chang Mo, Rong‐Rong Jia, Jian‐Hong Zhong – 5 December 2018

Bilon Khambu, Tiangang Li, Shengmin Yan, Changshun Yu, Xiaoyun Chen, Michael Goheen, Yong Li, Jingmei Lin, Oscar W. Cummings, Youngmin A. Lee, Scott Friedman, Zheng Dong, Gen‐Sheng Feng, Shangwei Wu, Xiao‐Ming Yin – 5 December 2018 – Autophagy is important for hepatic homeostasis, nutrient regeneration, and organelle quality control. We investigated the mechanisms by which liver injury occurred in the absence of autophagy function.