Longterm Risk of Solid Organ De Novo Malignancies After Liver Transplantation: A French National Study on 11,226 Patients

Olivier Sérée, Mario Altieri, Elodie Guillaume, Rémy De Mil, Thierry Lobbedez, Philip Robinson, Philippe Segol, Ephrem Salamé, Armand Abergel, Olivier Boillot, Filomena Conti, Olivier Chazouillères, Maryline Debette‐Gratien, Dominique Debray, Géraldine Hery, Sébastien Dharancy, François Durand, Christophe Duvoux, Claire Francoz, Jean Gugenheim, Jean Hardwigsen, Pauline Houssel‐Debry, Emmanuel Jacquemin, Nassim Kamar, Marianne Latournerie, Pascal Lebray, Vincent Leroy, Alessandra Mazzola, Martine Neau‐Cransac, Georges‐Philippe Pageaux, Sylvie Radenne, Faouzi Saliba, Didier Samuel, Claire Van

Laparoscopic Donor Hepatectomy for Adult Living Donor Liver Transplantation Recipients

Choon Hyuck David Kwon, Gyu‐Seong Choi, Jong Man Kim, Chan Woo Cho, Jinsoo Rhu, Gaab Soo Kim, Dong Hyun Sinn, Jae‐Won Joh – 18 July 2018 – Even after 2 decades of experience in laparoscopic hepatectomy, data on purely laparoscopic approach for donor hepatectomy in adult living donor liver transplantation (LDLT) are limited. We report our initial experience of a purely laparoscopic approach for donor hepatectomy for adult recipients to explore its potential application in the management of donors.

Heat Shock Protein 90α–Dependent B‐Cell‐2–Associated Transcription Factor 1 Promotes Hepatocellular Carcinoma Proliferation by Regulating MYC Proto‐Oncogene c‐MYC mRNA Stability

Xueqiong Zhou, Ying Wen, Ye Tian, Meiling He, Xiangyu Ke, Zhizhou Huang, Yangfan He, Lixia Liu, Annette Scharf, Meiting Lu, Guowei Zhang, Yaotang Deng, Yuxia Yan, Matthias P. Mayer, Xuemei Chen, Fei Zou – 17 July 2018 – B‐cell lymphoma 2 (Bcl‐2)‐associated transcription factor 1 (Bclaf1) is known to be involved in diverse biological processes, but, to date, there has been no evidence for any functional role of Bclaf1 in hepatocellular carcinoma (HCC) progression.

Nonheavy Drinking and Worsening of Noninvasive Fibrosis Markers in Nonalcoholic Fatty Liver Disease: A Cohort Study

Yoosoo Chang, Yong Kyun Cho, Yejin Kim, Eunju Sung, Jiin Ahn, Hyun‐Suk Jung, Kyung Eun Yun, Hocheol Shin, Seungho Ryu – 17 July 2018 – The effect of modest alcohol consumption on fibrosis progression in the general population with nonalcoholic fatty liver disease (NAFLD) remains unclear. We examined the association of nonheavy alcohol consumption with worsening of noninvasive fibrosis indices in a large‐scale, low‐risk population with NAFLD. A cohort study was performed in 58,927 Korean adults with NAFLD and low fibrosis scores who were followed for a median of 4.9 years.

Primary Biliary Cholangitis in Medicare Population: The Impact on Mortality and Resource Use

Mehmet Sayiner, Pegah Golabi, Maria Stepanova, Issah Younossi, Fatema Nader, Andrei Racila, Zobair M. Younossi – 17 July 2018 – Primary biliary cholangitis (PBC) is a disease of small bile ducts, which can lead to morbidity and mortality. Our aim was to assess recent trends in mortality and healthcare use of PBC patients in the Medicare program. Data from Medicare beneficiaries between 2005 and 2015 (5% random samples) were used. The diagnosis of PBC was established with International Classification of Diseases‐9 code 571.6 used for both primary and secondary diagnoses.

Liver‐Selective MMP‐9 Inhibition in the Rat Eliminates Ischemia‐Reperfusion Injury and Accelerates Liver Regeneration

Xiangdong Wang, Ana C. Maretti‐Mira, Lei Wang, Laurie D. DeLeve – 17 July 2018 – Recruitment of liver sinusoidal endothelial cell progenitor cells (sprocs) from the bone marrow by vascular endothelial growth factor‐stromal cell‐derived factor‐1 (VEGF‐sdf‐1) signaling promotes recovery from injury and drives liver regeneration. Matrix metalloproteinases (MMPs) can proteolytically cleave VEGF, which might inhibit progenitor cell recruitment, but systemic matrix metalloproteinase inhibition might prevent efflux of progenitors from the bone marrow.

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