Jiaye Liu, Tao Li, Li Zhang, Aiqiang Xu – 18 December 2018 – In actual clinical practice, infinite nucleos(t)ide analogues (NAs) treatment for chronic hepatitis B virus (HBV) infection is unrealistic. The most commonly used endpoint is suppression of HBV DNA to undetectable levels with normalization of alanine aminotransferase. However, this criterion for cessation of treatment is associated with various incidences of virological and clinical relapse.

Wayel Jassem, Emmanuel Xystrakis, Yasmeen G. Ghnewa, Muhammed Yuksel, Oltin Pop, Marc Martinez‐Llordella, Yamen Jabri, Xiaohong Huang, Juan J. Lozano, Alberto Quaglia, Alberto Sanchez‐Fueyo, Constantin C. Coussios, Mohamed Rela, Peter Friend, Nigel Heaton, Yun Ma – 18 December 2018 – Liver transplantation (LT) is a successful treatment for patients with liver failure. However, organ shortage results in over 11% of patients losing their chance of a transplant attributed to liver decompensation (LD) and death.

Lisa Katharina Maresch, Pia Benedikt, Ursula Feiler, Sandra Eder, Kathrin A. Zierler, Ulrike Taschler, Stephanie Kolleritsch, Thomas O. Eichmann, Gabriele Schoiswohl, Christina Leopold, Beatrix I. Wieser, Caroline Lackner, Thomas Rülicke, Jan van Klinken, Dagmar Kratky, Tarek Moustafa, Gerald Hoefler, Guenter Haemmerle – 17 December 2018 – Murine hepatic carboxylesterase 2c (Ces2c) and the presumed human ortholog carboxylesterase 2 (CES2) have been implicated in the development of nonalcoholic fatty liver disease (NAFLD) in mice and obese humans.

Ju Dong Yang, Tushar Patel – 17 December 2018

Reenam S. Khan, Fernando Bril, Kenneth Cusi, Philip N. Newsome – 16 December 2018 – Nonalcoholic fatty liver disease (NAFLD) has an estimated prevalence of 25% in the general population, and cirrhosis secondary to nonalcoholic steatohepatitis (NASH) is predicted to become the leading cause of liver transplantation, yet there is a lack of effective licensed treatments for these conditions. There is a close relationship between insulin resistance (IR) and NAFLD, with prevalence of NAFLD being 5‐fold higher in patients with diabetes compared to those without.

Reenam S. Khan, Fernando Bril, Kenneth Cusi, Philip N. Newsome – 16 December 2018 – Nonalcoholic fatty liver disease (NAFLD) has an estimated prevalence of 25% in the general population, and cirrhosis secondary to nonalcoholic steatohepatitis (NASH) is predicted to become the leading cause of liver transplantation, yet there is a lack of effective licensed treatments for these conditions. There is a close relationship between insulin resistance (IR) and NAFLD, with prevalence of NAFLD being 5‐fold higher in patients with diabetes compared to those without.

Chih‐Lang Lin, Yu‐De Chu, Chau‐Ting Yeh – 15 December 2018

Yun‐Shan Wang, Lutao Du, Xingsi Liang, Peng Meng, Lei Bi, Yu‐li Wang, Chuanxin Wang, Bo Tang – 15 December 2018 – Sirtuin 4 (SIRT4) has been reported to play a vital role in the maintenance of glutamine catabolism and adenosine triphosphate (ATP) homeostasis, but its character in hepatocellular carcinomas (HCCs) remains obscure. In this study, we observed low expression of SIRT4 in both HCC cell lines and HCCs from patients. Decreased disease‐free survival time is associated with low tumor levels of SIRT4 in patients.

Chih‐Lang Lin, Yu‐De Chu, Chau‐Ting Yeh – 15 December 2018

Matthew McConnell, Joseph K. Lim – 14 December 2018