Liver Angiopoietin‐2 Is a Key Predictor of DeNovo or Recurrent Hepatocellular Cancer After Hepatitis CVirus Direct‐Acting Antivirals

Francesca Faillaci, Luca Marzi, Rosina Critelli, Fabiola Milosa, Filippo Schepis, Elena Turola, Silvia Andreani, Gabriele Vandelli, Veronica Bernabucci, Barbara Lei, Federica D'Ambrosio, Laura Bristot, Luisa Cavalletto, Liliana Chemello, Pamela Sighinolfi, Paola Manni, Antonino Maiorana, Cristian Caporali, Marcello Bianchini, Maria Marsico, Laura Turco, Nicola de Maria, Mariagrazia Del Buono, Paola Todesca, Luca di Lena, Dante Romagnoli, Paolo Magistri, Fabrizio di Benedetto, Savino Bruno, Gloria Taliani, Gianluigi Giannelli, Maria‐Luz Martinez‐Chantar, Erica Villa – 31 March 2018 – Recent

Clinical Course of Hepatic Artery Thrombosis After Living Donor Liver Transplantation Using the Right Lobe

Ho Joong Choi, Dong Goo Kim, Yumi Kim, Bong Jun Kwak, Jae Hyun Han, Tae Ho Hong, Young Kyoung You – 31 March 2018 – Hepatic artery thrombosis (HAT) can result in biliary tree necrosis and graft loss, necessitating retransplantation. The most effective treatment approach is still controversial. This study was performed to review the outcomes of HAT after living donor liver transplantation (LDLT) and to clarify the feasibility of different strategies. From May 1996 to August 2017, LDLT using the right lobe was performed in 827 adult patients in our center.

Biliary Atresia: Clinical and Research Challenges for the Twenty‐First Century

Jorge A. Bezerra, Rebecca G. Wells, Cara L. Mack, Saul J. Karpen, Jay H. Hoofnagle, Edward Doo, Ronald J. Sokol – 31 March 2018 – Biliary atresia (BA) is a fibroinflammatory disease of the intrahepatic and extrahepatic biliary tree. Surgical hepatic portoenterostomy (HPE) may restore bile drainage, but progression of the intrahepatic disease results in complications of portal hypertension and advanced cirrhosis in most children.

Blocking H1/H2 histamine receptors inhibits damage/fibrosis in Mdr2–/– mice and human cholangiocarcinoma tumorigenesis

Lindsey Kennedy, Laura Hargrove, Jennifer Demieville, Walker Karstens, Hannah Jones, Sharon DeMorrow, Fanyin Meng, Pietro Invernizzi, Francesca Bernuzzi, Gianfranco Alpini, Steven Smith, Austin Akers, Vik Meadows, Heather Francis – 30 March 2018 – Primary sclerosing cholangitis (PSC) patients are at risk of developing cholangiocarcinoma (CCA). We have shown that (1) histamine increases biliary hyperplasia through H1/H2 histamine receptors (HRs) and (2) histamine levels increase and mast cells (MCs) infiltrate during PSC and CCA.

Landscape of immune microenvironment in hepatocellular carcinoma and its additional impact on histological and molecular classification

Yutaka Kurebayashi, Hidenori Ojima, Hanako Tsujikawa, Naoto Kubota, Junki Maehara, Yuta Abe, Minoru Kitago, Masahiro Shinoda, Yuko Kitagawa, Michiie Sakamoto – 30 March 2018 – Immune cells constitute an important element of tumor tissue. Accumulating evidence indicates their clinicopathological significance in predicting prognosis and therapeutic efficacy. Nonetheless, the combinations of immune cells forming the immune microenvironment and their association with histological findings remain largely unknown.

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