Pediatric cirrhotic cardiomyopathy: Impact on liver transplant outcomes

Norman Junge, Claudia Junge, Julian Schröder, Eva‐Doreen Pfister, Christoph Leiskau, Dagmar Hohmann, Philipp Beerbaum, Ulrich Baumann – 10 April 2018 – In adults, cirrhotic cardiomyopathy (CCM) has a significant incidence and impact on liver transplantation. For pediatric liver transplantation (pLT), data on liver‐induced cardiac changes are scarce, and in particular, the comparison between cirrhotic and noncirrhotic liver disease has not been investigated.

Hepatoma cell‐secreted exosomal microRNA‐103 increases vascular permeability and promotes metastasis by targeting junction proteins

Jian‐Hong Fang, Zi‐Jun Zhang, Li‐Ru Shang, Yu‐Wei Luo, Yi‐Fang Lin, Yunfei Yuan, Shi‐Mei Zhuang – 10 April 2018 – Increased vascular permeability facilitates metastasis. Emerging evidence indicates that secreted microRNAs (miRNAs) may mediate the crosstalk between cancer and stromal cells. To date, whether and how secreted miRNAs affect vascular permeability remains unclear. Based on deep sequencing and quantitative PCR, we found that higher level of serum miR‐103 was associated with higher metastasis potential of hepatocellular carcinoma (HCC).

Cost‐effectiveness of antiviral treatment after resection in hepatitis B virus–related hepatocellular carcinoma patients with compensated cirrhosis

Li Xie, Juan Yin, Ruyi Xia, Guihua Zhuang – 7 April 2018 – Hepatocellular carcinoma (HCC) imposes a heavy disease burden on China due to its high morbidity and mortality. China accounts for about 50% of the total new cases and deaths worldwide. Most cases are related to hepatitis B virus (HBV) infection and are associated with cirrhosis at diagnosis. Antiviral treatment with nucleos(t)ide analogues (NAs) after resection in HBV‐related HCC can reduce recurrence and improve survival. Such treatment is in fact recommended by Chinese guidelines.

Disruption of Renal Arginine Metabolism Promotes Kidney Injury in Hepatorenal Syndrome in Mice

Zoltan V. Varga, Katalin Erdelyi, Janos Paloczi, Resat Cinar, Zsuzsanna K. Zsengeller, Tony Jourdan, Csaba Matyas, Balazs Tamas Nemeth, Adrien Guillot, Xiaogang Xiang, Adam Mehal, György Haskó, Isaac E. Stillman, Seymour Rosen, Bin Gao, George Kunos, Pal Pacher – 6 April 2018 – Tubular dysfunction is an important feature of renal injury in hepatorenal syndrome (HRS) in patients with end‐stage liver disease. The pathogenesis of kidney injury in HRS is elusive, and there are no clinically relevant rodent models of HRS.

A novel multimarker assay for the phenotypic profiling of circulating tumor cells in hepatocellular carcinoma

Colin M. Court, Shuang Hou, Paul Winograd, Nicholas H. Segel, Qingyu Wilda Li, Yazhen Zhu, Saeed Sadeghi, Richard S. Finn, Ekambaram Ganapathy, Min Song, Samuel W. French, Bita V. Naini, Shonan Sho, Fady M. Kaldas, Ronald W. Busuttil, James S. Tomlinson, Hsian‐Rong Tseng, Vatche G. Agopian – 6 April 2018 – Current clinicopathologic staging systems and serum biomarkers poorly discriminate tumor biology in hepatocellular carcinoma (HCC), with high recurrence rates following curative‐intent surgical resection and liver transplantation (LT).

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