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Jacqueline G. O’Leary, K. Rajender Reddy, Florence Wong, Guadalupe Garcia‐Tsao, Patrick S. Kamath, Jasmohan S. Bajaj – 16 April 2018

Pregnancy outcomes following single and repeat liver transplantation: An international 2‐center cohort

Nusrat Zaffar, Elisabeth Soete, Shital Gandhi, Parastoo Sayyar, Tim Van Mieghem, Rohan D'Souza – 14 April 2018 – Due to advances in obstetric and transplant medicine, women with a history of liver transplantation can have successful pregnancies. However, data on pregnancy outcomes is still limited, especially for women who have had a repeat liver transplant following graft rejection. This retrospective study compares pregnancy outcomes in women with single and repeat liver transplants managed at 2 tertiary hospitals in Toronto, Canada and Leuven, Belgium.

Neutrophils alleviate fibrosis in the CCl4‐induced mouse chronic liver injury model

Eiko Saijou, Yutaka Enomoto, Michitaka Matsuda, Cindy Yuet‐Yin Kok, Shizuo Akira, Minoru Tanaka, Atsushi Miyajima – 12 April 2018 – Tribbles pseudokinase 1 (Trib1) is a negative regulator of CCAAT/enhancer binding protein α (C/EBPα) and is known to induce granulopoiesis while suppressing monocyte differentiation. Loss of Trib1 was previously shown to increase the neutrophil population in the spleen but lead to M2‐like macrophage reduction.

Hepatic CREBZF couples insulin to lipogenesis by inhibiting insig activity and contributes to hepatic steatosis in diet‐induced insulin‐resistant mice

Feifei Zhang, Zhimin Hu, Gaopeng Li, Shaofeng Huo, Fengguang Ma, Aoyuan Cui, Yaqian Xue, Yamei Han, Qi Gong, Jing Gao, Hua Bian, Zhuoxian Meng, Haifu Wu, Gang Long, Yi Tan, Yan Zhang, Xu Lin, Xin Gao, Aimin Xu, Yu Li – 10 April 2018 – Insulin is critical for the regulation of de novo fatty acid synthesis, which converts glucose to lipid in the liver. However, how insulin signals are transduced into the cell and then regulate lipogenesis remains to be fully understood.

Influence of Progenitor‐Derived Regeneration Markers on Hepatitis C Virus–Related Cirrhosis Outcome (ANRS CO12 CirVir Cohort)

Dominique Wendum, Richard Layese, Nathalie Ganne‐Carrié, Valérie Bourcier, Fatiha Merabtene, Carole Cagnot, Emmanuel Sauce, Nathalie Barget, Pierre Bedossa, Benoit Terris, Janick Selves, Paulette Bioulac‐Sage, Nathalie Sturm, Christophe Sattonnet, Pierre Nahon, Françoise Roudot‐Thoraval, Marianne Ziol, for the ANRS CO12 CirVir Group – 10 April 2018 – Progenitor‐derived regeneration gives rise to the aberrant expression of biliary markers such as cytokeratin 7 (K7) and epithelial cell adhesion molecule (EpCAM) in hepatocytes.

Eversion Bile Duct Anastomosis: A Safe Alternative for Bile Duct Size Discrepancy in Deceased Donor Liver Transplantation

Pilar Leal‐Leyte, Greg J. McKenna, Richard M. Ruiz, Tiffany L. Anthony, Giovanna Saracino, Giuliano Testa, Goran B. Klintmalm, Peter T. W. Kim – 10 April 2018 – Bile duct size discrepancy in liver transplantation may increase the risk of biliary complications (BCs). The aim of this study was to evaluate the safety and outcomes of the eversion bile duct anastomosis technique in deceased donor liver transplantation (DDLT) with duct‐to‐duct anastomosis.

Living Donation Versus Donation After Circulatory Death Liver Transplantation for Low Model for End‐Stage Liver Disease Recipients

Catherine E. Kling, James D. Perkins, Jorge D. Reyes, Martin I. Montenovo – 10 April 2018 – In this era of organ scarcity, living donor liver transplantation (LDLT) is an alternative to using deceased donors, and in Western countries, it is more often used for recipients with low Model for End‐Stage Liver Disease (MELD) scores. We sought to compare the patient survival and graft survival between recipients of liver transplantation from living donors and donation after circulatory death (DCD) donors in patients with low MELD scores.

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