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Jacqueline G. O’Leary, K. Rajender Reddy, Florence Wong, Guadalupe Garcia‐Tsao, Patrick S. Kamath, Jasmohan S. Bajaj – 16 April 2018

Extrahepatic cancers are the leading cause of death in patients achieving hepatitis B virus control or hepatitis C virus eradication

Manon Allaire, Pierre Nahon, Richard Layese, Valérie Bourcier, Carole Cagnot, Patrick Marcellin, Dominique Guyader, Stanislas Pol, Dominique Larrey, Victor De Lédinghen, Denis Ouzan, Fabien Zoulim, Dominique Roulot, Albert Tran, Jean‐Pierre Bronowicki, Jean‐Pierre Zarski, Ghassan Riachi, Paul Calès, Jean‐Marie Péron, Laurent Alric, Marc Bourlière, Philippe Mathurin, Jean‐Frédéric Blanc, Armand Abergel, Lawrence Serfaty, Ariane Mallat, Jean‐Didier Grangé, Pierre Attali, Yannick Bacq, Claire Wartelle, Thông Dao, Dominique Thabut, Christophe Pilette, Christine Silvain, Christos Christidis, Eri

Metastasis‐associated lung adenocarcinoma transcript 1 as a common molecular driver in the pathogenesis of nonalcoholic steatohepatitis and chronic immune‐mediated liver damage

Silvia Sookoian, Diego Flichman, Martin E. Garaycoechea, Julio San Martino, Gustavo O. Castaño, Carlos J. Pirola – 16 April 2018 – Long noncoding RNAs (lncRNAs) are functional molecules that orchestrate gene expression.

Baseline urine metabolic phenotype in patients with severe alcoholic hepatitis and its association with outcome

Jaswinder Singh Maras, Sukanta Das, Shvetank Sharma, Saggere M. Shasthry, Benoit Colsch, Christophe Junot, Richard Moreau, Shiv Kumar Sarin – 16 April 2018 – Severe alcoholic hepatitis (SAH) has a high mortality rate, and corticosteroid therapy is effective in 60% patients. This study aimed to investigate a baseline metabolic phenotype that could help stratify patients not likely to respond to steroid therapy and to have an unfavorable outcome.

Hepatocellular Carcinoma‐Associated Protein TD26 Interacts and Enhances Sterol Regulatory Element‐Binding Protein 1 Activity to Promote Tumor Cell Proliferation and Growth

Chenchen Wang, Ying Tong, Yankai Wen, Jie Cai, Han Guo, Lifeng Huang, Min Xu, Mingxuan Feng, Xiaosong Chen, Jianjun Zhang, Hailong Wu, Xiaoni Kong, Qiang Xia – 16 April 2018 – Hepatocellular carcinoma (HCC) is a leading cause of cancer‐related death worldwide. Increased lipogenesis has been reported to play a critical role in HCC progression. However, the underlying mechanism contributing to lipogenesis increase in HCC remains elusive. Here, we show that HCC‐associated protein TD26 (TD26) was highly expressed in HCC tumor tissues compared to matched normal tissues.

Pregnancy outcomes following single and repeat liver transplantation: An international 2‐center cohort

Nusrat Zaffar, Elisabeth Soete, Shital Gandhi, Parastoo Sayyar, Tim Van Mieghem, Rohan D'Souza – 14 April 2018 – Due to advances in obstetric and transplant medicine, women with a history of liver transplantation can have successful pregnancies. However, data on pregnancy outcomes is still limited, especially for women who have had a repeat liver transplant following graft rejection. This retrospective study compares pregnancy outcomes in women with single and repeat liver transplants managed at 2 tertiary hospitals in Toronto, Canada and Leuven, Belgium.

Neutrophils alleviate fibrosis in the CCl4‐induced mouse chronic liver injury model

Eiko Saijou, Yutaka Enomoto, Michitaka Matsuda, Cindy Yuet‐Yin Kok, Shizuo Akira, Minoru Tanaka, Atsushi Miyajima – 12 April 2018 – Tribbles pseudokinase 1 (Trib1) is a negative regulator of CCAAT/enhancer binding protein α (C/EBPα) and is known to induce granulopoiesis while suppressing monocyte differentiation. Loss of Trib1 was previously shown to increase the neutrophil population in the spleen but lead to M2‐like macrophage reduction.

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