Juan‐Li Duan, Bai Ruan, Xian‐Chun Yan, Liang Liang, Ping Song, Zi‐Yan Yang, Yuan Liu, Ke‐Feng Dou, Hua Han, Lin Wang – 8 February 2018 – Liver sinusoidal endothelial cells (LSECs) critically regulate liver homeostasis and diseases through angiocrine factors. Notch is critical in endothelial cells (ECs). In the current study, Notch signaling was activated by inducible EC‐specific expression of the Notch intracellular domain (NIC). We found that endothelial Notch activation damaged liver homeostasis.

Delia Blaya, Beatriz Aguilar‐Bravo, Fengjie Hao, Silvia Casacuberta‐Serra, Mar Coll, Luis Perea, Júlia Vallverdú, Isabel Graupera, Elisa Pose, Laura Llovet, Jordi Barquinero, Francisco Javier Cubero, Juan Caballería, Pere Ginès, Pau Sancho‐Bru – 8 February 2018 – MicroRNA 155 (miR‐155) is involved in immune and inflammatory diseases and is associated with liver fibrosis and steatohepatitis. However, the mechanisms involved in miR‐155 regulation of liver injury are largely unknown.

Yuri L. Boteon, Barney T. F. Stephenson, Desley A. H. Neil, Darius F. Mirza, Simon C. Afford, Hynek Mergental – 7 February 2018

Adrian P. Mansini, Maria J. Lorenzo Pisarello, Kristen M. Thelen, Maetzin Cruz‐Reyes, Estanislao Peixoto, Sujeong Jin, Brynn N. Howard, Christy E. Trussoni, Gabriella B. Gajdos, Nicholas F. LaRusso, Maria J. Perugorria, Jesus M. Banales, Sergio A. Gradilone – 6 February 2018 – Cholangiocytes normally express primary cilia, a multisensory organelle that detects signals from the cellular environment. Cilia are significantly reduced in cholangiocarcinoma (CCA) by a mechanism involving overexpression of histone deacetylase 6 (HDAC6).

Renwei Jing, Xiaoli Zhou, Jingwen Zhao, Yushuang Wei, Bingfeng Zuo, Abin You, Quan Rao, Xianjun Gao, Rong Yang, Lu Chen, Zhen Lu, Qibing Zhou, Ning Zhang, HaiFang Yin – 5 February 2018 – Early detection and clear delineation of microscopic lesions during surgery are critical to the prognosis and survival of patients with hepatocellular carcinoma (HCC), a devastating malignancy without effective treatments except for resection. Tools to specifically identify and differentiate micronodules from normal tissue in HCC patients can have a positive impact on survival.

Meng Wang, Cynthia Ju – 5 February 2018

David E. Kleiner – 5 February 2018

Norah A. Terrault, Anna S.F. Lok, Brian J. McMahon, Kyong‐Mi Chang, Jessica P. Hwang, Maureen M. Jonas, Robert S. Brown, Natalie H. Bzowej, John B. Wong – 5 February 2018

Renwei Jing, Xiaoli Zhou, Jingwen Zhao, Yushuang Wei, Bingfeng Zuo, Abin You, Quan Rao, Xianjun Gao, Rong Yang, Lu Chen, Zhen Lu, Qibing Zhou, Ning Zhang, HaiFang Yin – 5 February 2018 – Early detection and clear delineation of microscopic lesions during surgery are critical to the prognosis and survival of patients with hepatocellular carcinoma (HCC), a devastating malignancy without effective treatments except for resection. Tools to specifically identify and differentiate micronodules from normal tissue in HCC patients can have a positive impact on survival.

Norah A. Terrault, Anna S.F. Lok, Brian J. McMahon, Kyong‐Mi Chang, Jessica P. Hwang, Maureen M. Jonas, Robert S. Brown, Natalie H. Bzowej, John B. Wong – 5 February 2018