William Carey – 14 February 2018

Naga Chalasani, on behalf of the Writing Group for the AASLD NAFLD Practice Gudiance – 14 February 2018

Wei Zhu, Yibing Peng, Lan Wang, Yuan Hong, Xiaotao Jiang, Qi Li, Heping Liu, Lei Huang, Juan Wu, Esteban Celis, Todd Merchen, Edward Kruse, Yukai He – 14 February 2018 – Hepatocellular carcinoma (HCC) is the major form of liver cancer for which there is no effective therapy. Genetic modification with T‐cell receptors (TCRs) specific for HCC‐associated antigens, such as α‐fetoprotein (AFP), can potentially redirect human T cells to specifically recognize and kill HCC tumor cells to achieve antitumor effects.

Junna Wang, Jiajun Li, Quan Zhou, Dandan Zhang, Qiu Bi, Yulin Wu, Wenxiang Huang – 13 February 2018 – Numerous studies have investigated the prognosis value of the liver stiffness measurement (LSM) by transient elastography in assessing the risk of liver‐related events (LREs) and all‐cause mortality in patients with chronic liver disease (CLD). However, the shape of the dose–response relationship between them remains unclear.

Yosuke Osawa, Ekumi Kojika, Yukiko Hayashi, Masamichi Kimura, Koji Nishikawa, Sachiyo Yoshio, Hiroyoshi Doi, Tatsuya Kanto, Kiminori Kimura – 13 February 2018 – Hepatocyte apoptosis has been implicated in the progression of nonalcoholic steatohepatitis. However, it is unclear whether the induction of tumor necrosis factor (TNF)‐α‐mediated hepatocyte apoptosis in the simple fatty liver triggers liver fibrosis. To address this question, high‐fat diet‐fed mice were repeatedly administered D‐galactosamine, which increases the sensitivity of hepatocytes to TNF‐α‐mediated apoptosis.

Stephen D. Zucker, Michael W. Fried – 12 February 2018

Ashish Mishra, Alexis Lo, Grace S. Lee, Benjamin Samstein, Peter S. Yoo, Matthew H. Levine, David S. Goldberg, Abraham Shaked, Kim M. Olthoff, Peter L. Abt – 10 February 2018 – Kidney paired exchange (KPE) constitutes 12% of all living donor kidney transplantations (LDKTs) in the United States. The success of KPE programs has prompted many in the liver transplant community to consider the possibility of liver paired exchange (LPE). Though the idea seems promising, the application has been limited to a handful of centers in Asia.

Tim F. Greten – 10 February 2018

Vincenzo Mazzaferro, Michele Droz dit Busset, Sherrie Bhoori – 9 February 2018

Anna L. Lang, Liya Chen, Gavin D. Poff, Wen‐Xing Ding, Russel A. Barnett, Gavin E. Arteel, Juliane I. Beier – 9 February 2018 – Vinyl chloride (VC), a common industrial organochlorine and environmental pollutant, has been shown to directly cause hepatic angiosarcoma and toxicant‐associated steatohepatitis at high exposure levels. However, the impact of lower concentrations of VC on the progression of underlying liver diseases (e.g., nonalcoholic fatty liver disease [NAFLD]) is unclear.