mTOR Signaling in X/A‐Like Cells Contributes to Lipid Homeostasis in Mice

Ziru Li, Ruili Yu, Wenzhen Yin, Yan Qin, Liangxiao Ma, Michael Mulholland, Weizhen Zhang – 23 August 2018 – Gastric mechanistic target of rapamycin (mTOR) signaling is inversely associated with the expression and secretion of ghrelin, a 28‐aa peptide hormone produced by gastric X/A‐like cells. Ghrelin contributes to obesity and hepatic steatosis. We sought to control global lipid metabolism via the manipulation of gastric mTOR signaling in X/A‐like cells. We established a ghrl‐cre transgene in which the Cre enzyme is expressed in X/A‐like cells under the control of the ghrelin‐promoter.

Integrating the Epigenome to Identify Drivers of Hepatocellular Carcinoma

Ryan A. Hlady, Aishwarya Sathyanarayan, Joyce J. Thompson, Dan Zhou, Qunfeng Wu, Kien Pham, Jeong‐Heon Lee, Chen Liu, Keith D. Robertson – 22 August 2018 – Disruption of epigenetic mechanisms has been intimately linked to the etiology of human cancer. Understanding how these epigenetic mechanisms (including DNA methylation [5mC], hydroxymethylation [5hmC], and histone post‐translational modifications) work in concert to drive cancer initiation and progression remains unknown. Hepatocellular carcinoma (HCC) is increasing in frequency in Western countries but lacks efficacious treatments.

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