Carcinoembryonic antigen‐related cell adhesion molecule 1 controls IL‐2‐dependent regulatory T‐cell induction in immune‐mediated hepatitis in mice

Andrea Kristina Horst, Claudia Wegscheid, Christoph Schaefers, Birgit Schiller, Katrin Neumann, Sebastian Lunemann, Annika E. Langeneckert, Karl J. Oldhafer, Christina Weiler‐Normann, Karl S. Lang, Bernhard B. Singer, Marcus Altfeld, Linda Diehl, Gisa Tiegs – 29 January 2018 – A dysbalance between effector T cells (Tconv) and regulatory T cells (Tregs) and impaired Treg function can cause autoimmune liver disease. Therefore, it is important to identify molecular mechanisms that control Treg homeostasis.

Wait‐list mortality of young patients with Biliary atresia: Competing risk analysis of a eurotransplant registry–based cohort

Hubert P. J. van der Doef, Patrick F. van Rheenen, Marieke van Rosmalen, Xavier Rogiers, Henkjan J. Verkade, for pediatric liver transplantation centers of Eurotransplant – 29 January 2018 – Liver transplantation (LT) is the standard treatment for biliary atresia (BA) patients with end‐stage liver disease. The prognosis after LT has steadily improved, but overall prognosis of BA patients is also determined by mortality before LT.

Exploring opportunities to prevent cirrhosis admissions in the emergency department: A multicenter multidisciplinary survey

Shazia Mehmood Siddique, Meghan Lane‐Fall, Matthew J. McConnell, Neha Jakhete, James Crismale, Stefanie Porges, Vandana Khungar, Shivan J. Mehta, David Goldberg, Zhiping Li, Thomas Schiano, Linda Regan, Clinton Orloski, Judy A. Shea – 26 January 2018 – Patients with cirrhosis have high admission and readmission rates, and it is estimated that a quarter are potentially preventable. Little data are available regarding nonmedical factors impacting triage decisions in this patient population.

Khat chewing increases the risk for developing chronic liver disease: A hospital‐based case–control study

Stian Magnus Staurung Orlien, Irene Sandven, Nega Belay Berhe, Nejib Yusuf Ismael, Tekabe Abdosh Ahmed, Kathrine Stene‐Johansen, Svein Gunnar Gundersen, Marsha Yvonne Morgan, Asgeir Johannessen – 25 January 2018 – The chewing of the leaves of Catha edulis (khat) has been implicated in the development of liver disease, but no controlled observations have been undertaken. The objective of the present study was to determine whether khat chewing is associated with development of chronic liver disease (CLD).

Hypothermic oxygenated machine perfusion reduces bile duct reperfusion injury after transplantation of donation after circulatory death livers

Rianne van Rijn, Otto B. van Leeuwen, Alix P. M. Matton, Laura C. Burlage, Janneke Wiersema‐Buist, Marius C. van den Heuvel, Ruben H. J. de Kleine, Marieke T. de Boer, Annette S. H. Gouw, Robert J. Porte – 25 January 2018 – Dual hypothermic oxygenated machine perfusion (DHOPE) of the liver has been advocated as a method to reduce ischemia/reperfusion injury (IRI). This study aimed to determine whether DHOPE reduces IRI of the bile ducts in donation after circulatory death (DCD) liver transplantation.

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