Hepatic PPARα function is controlled by polyubiquitination and proteasome‐mediated degradation through the coordinated actions of PAQR3 and HUWE1

Zilong Zhao, Daqian Xu, Zheng Wang, Lin Wang, Ruomei Han, Zhenzhen Wang, Lujian Liao, Yan Chen – 13 January 2018 – Peroxisome proliferator‐activated receptor α (PPARα) is a key transcriptional factor that regulates hepatic lipid catabolism by stimulating fatty acid oxidation and ketogenesis in an adaptive response to nutrient starvation. However, how PPARα is regulated by posttranslational modification is poorly understood.

Cellular Membrane Trafficking Machineries Used by the Hepatitis Viruses

Jun Inoue, Masashi Ninomiya, Tooru Shimosegawa, Mark A. McNiven – 13 January 2018 – While the life cycles of hepatitis viruses (A, B, C, D, and E) have been modestly characterized, recent intensive studies have provided new insights. Because these viruses “hijack” the membrane trafficking of the host cell machinery during replicative propagation, it is essential to determine and understand these specific cellular pathways. Hepatitis B virus (HBV) and hepatitis C virus are well known as leading causes of liver cirrhosis and hepatocellular carcinoma.

Cellular Membrane Trafficking Machineries Used by the Hepatitis Viruses

Jun Inoue, Masashi Ninomiya, Tooru Shimosegawa, Mark A. McNiven – 13 January 2018 – While the life cycles of hepatitis viruses (A, B, C, D, and E) have been modestly characterized, recent intensive studies have provided new insights. Because these viruses “hijack” the membrane trafficking of the host cell machinery during replicative propagation, it is essential to determine and understand these specific cellular pathways. Hepatitis B virus (HBV) and hepatitis C virus are well known as leading causes of liver cirrhosis and hepatocellular carcinoma.

Improved portal vein venoplasty with an autogenous patch in pediatric living donor liver transplantation

Mingxuan Feng, Ping Wan, Bijun Qiu, Tao Zhou, Yi Luo, Lihong Gu, Jiachang Chi, Chengpeng Zhong, Yefeng Lu, Jianjun Zhang, Qiang Xia – 12 January 2018 – A stenotic or hypoplastic portal vein (PV) represents a challenge for PV reconstruction in pediatric living donor liver transplantation (LDLT). Several PV venoplastic techniques have been developed. However, we still seek improved venoplastic techniques with better efficacy and compatibility. From June 2016 to July 2017, 271 LDLT procedures were performed at the Department of Liver Surgery, Renji Hospital.

Coronary artery disease in decompensated patients undergoing liver transplantation evaluation

Samarth S. Patel, Eiman Nabi, Luis Guzman, Antonio Abbate, Chandra Bhati, Richard T. Stravitz, Trevor Reichman, Scott C. Matherly, Carolyn Driscoll, Hannah Lee, Velimir A. Luketic, Richard K. Sterling, Arun J. Sanyal, Vaishali Patel, Marlon Levy, Mohammad Shadab Siddiqui – 12 January 2018 – Coronary artery disease (CAD) is an important contributor to morbidity and mortality in patients undergoing liver transplantation (LT). However, the current literature is limited by sampling bias and nondefinitive assessment of CAD.

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