Hepatocellular carcinoma–related cyclin D1 is selectively regulated by autophagy degradation system

Shan‐Ying Wu, Sheng‐Hui Lan, Shang‐Rung Wu, Yen‐Chi Chiu, Xi‐Zhang Lin, Ih‐Jen Su, Ting‐Fen Tsai, Chia‐Jui Yen, Tsung‐Hsueh Lu, Fu‐Wen Liang, Chung‐Yi Li, Huey‐Jen Su, Chun‐Li Su, Hsiao‐Sheng Liu – 12 January 2018 – Dysfunction of degradation machineries causes cancers, including hepatocellular carcinoma (HCC). Overexpression of cyclin D1 in HCC has been reported. We previously reported that autophagy preferentially recruits and degrades the oncogenic microRNA (miR)‐224 to prevent HCC.

Serologic responses and effectiveness of hepatitis A vaccination among human immunodeficiency virus–positive individuals during the outbreak of acute hepatitis A

Kuan‐Yin Lin, Szu‐Min Hsieh, Hsin‐Yun Sun, Yi‐Chun Lo, Wang‐Huei Sheng, Yu‐Chung Chuang, Aristine Cheng, Sung‐Ching Pan, Guan‐Jhou Chen, Chien‐Ching Hung, Shan‐Chwen Chang – 12 January 2018 – Outbreaks of hepatitis A virus (HAV) infection have been occurring among men who have sex with men in the Asia‐Pacific region, the United States, and several European countries since June 2015 and recently among persons who are homeless and use illicit drugs in the United States.

MAIT cells are chronically activated in patients with autoimmune liver disease and promote profibrogenic hepatic stellate cell activation

Katrin Böttcher, Krista Rombouts, Francesca Saffioti, Davide Roccarina, Matteo Rosselli, Andrew Hall, TuVinh Luong, Emmanuel A. Tsochatzis, Douglas Thorburn, Massimo Pinzani – 12 January 2018 – Autoimmune liver diseases (AILDs) are chronic liver pathologies characterized by fibrosis and cirrhosis due to immune‐mediated liver damage.

Can genetic testing guide the therapy of cholestatic pruritus? A case of benign recurrent intrahepatic cholestasis type 2 with severe nasobiliary drainage‐refractory itch

Robert Holz, Andreas E. Kremer, Dieter Lütjohann, Hermann E. Wasmuth, Frank Lammert, Marcin Krawczyk – 10 January 2018 – Benign recurrent intrahepatic cholestasis (BRIC) is a peculiar familial disease caused by mutations of the genes encoding hepatocanalicular flippase for phosphatidylserine (ATP8B1; BRIC type 1) or the bile salt export pump (ABCB11; BRIC type 2). Here, we report on a patient with nasobiliary drainage‐refractory BRIC type 2 who improved under plasma separation and anion absorption therapy.

Disruption of adenosine 2A receptor exacerbates NAFLD through increasing inflammatory responses and SREBP1c activity

Yuli Cai, Honggui Li, Mengyang Liu, Ya Pei, Juan Zheng, Jing Zhou, Xianjun Luo, Wenya Huang, Linqiang Ma, Qiuhua Yang, Shaodong Guo, Xiaoqiu Xiao, Qifu Li, Tianshu Zeng, Fanyin Meng, Heather Francis, Shannon Glaser, Lulu Chen, Yuqing Huo, Gianfranco Alpini, Chaodong Wu – 9 January 2018 – Adenosine 2A receptor (A2AR) exerts protective roles in endotoxin‐ and/or ischemia‐induced tissue damage. However, the role for A2AR in nonalcoholic fatty liver disease (NAFLD) remains largely unknown.

Single‐cell analysis reveals cancer stem cell heterogeneity in hepatocellular carcinoma

Hongping Zheng, Yotsawat Pomyen, Maria Olga Hernandez, Caiyi Li, Ferenc Livak, Wei Tang, Hien Dang, Tim F. Greten, Jeremy L. Davis, Yongmei Zhao, Monika Mehta, Yelena Levin, Jyoti Shetty, Bao Tran, Anuradha Budhu, Xin Wei Wang – 9 January 2018 – Intratumor molecular heterogeneity of hepatocellular carcinoma is partly attributed to the presence of hepatic cancer stem cells (CSCs). Different CSC populations defined by various cell surface markers may contain different oncogenic drivers, posing a challenge in defining molecularly targeted therapeutics.

Offer acceptance practices and geographic variability in allocation model for end‐stage liver disease at transplant

Andrew Wey, Joshua Pyke, David P. Schladt, Sommer E. Gentry, Tim Weaver, Nicholas Salkowski, Bertram L. Kasiske, Ajay K. Israni, Jon J. Snyder – 9 January 2018 – Offer acceptance practices may cause geographic variability in allocation Model for End‐Stage Liver Disease (aMELD) score at transplant and could magnify the effect of donor supply and demand on aMELD variability.

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