Hepatocellular carcinoma–related cyclin D1 is selectively regulated by autophagy degradation system
Shan‐Ying Wu, Sheng‐Hui Lan, Shang‐Rung Wu, Yen‐Chi Chiu, Xi‐Zhang Lin, Ih‐Jen Su, Ting‐Fen Tsai, Chia‐Jui Yen, Tsung‐Hsueh Lu, Fu‐Wen Liang, Chung‐Yi Li, Huey‐Jen Su, Chun‐Li Su, Hsiao‐Sheng Liu – 12 January 2018 – Dysfunction of degradation machineries causes cancers, including hepatocellular carcinoma (HCC). Overexpression of cyclin D1 in HCC has been reported. We previously reported that autophagy preferentially recruits and degrades the oncogenic microRNA (miR)‐224 to prevent HCC.