Distinct clinical and magnetic resonance features of metastatic hepatocellular carcinoma treated with pembrolizumab: A case report of late response after pseudoprogression

Patrick Grierson, Danielle Crites, Marianna B. Ruzinova, Motoyo Yano, Kian‐Huat Lim – 19 December 2017 – There are few effective therapies for unresectable or metastatic hepatocellular carcinoma. Recent data have demonstrated efficacy of immune checkpoint blockade in this difficult to treat disease; however, clinical experience is limited. We report a case of hepatocellular carcinoma displaying pseudoprogression followed by a late response with novel magnetic resonance imaging features following treatment with the anti‐programmed cell death protein 1 agent pembrolizumab.

Extracellular vesicles from mice with alcoholic liver disease carry a distinct protein cargo and induce macrophage activation through heat shock protein 90

Banishree Saha, Fatemeh Momen‐Heravi, Istvan Furi, Karen Kodys, Donna Catalano, Anwesha Gangopadhyay, Reka Haraszti, Abhishek Satishchandran, Arvin Iracheta‐Vellve, Adeyinka Adejumo, Scott A. Shaffer, Gyongyi Szabo – 18 December 2017 – A salient feature of alcoholic liver disease (ALD) is Kupffer cell (KC) activation and recruitment of inflammatory monocytes and macrophages (MØs). These key cellular events of ALD pathogenesis may be mediated by extracellular vesicles (EVs).

Advance care planning (ACP) for specialists managing cirrhosis: A focus on patient‐centered care

Amanda Brisebois, Kathleen P. Ismond, Michelle Carbonneau, Jan Kowalczewski, Puneeta Tandon – 18 December 2017 – Advance care planning (ACP) and goals of care designation (GCD) are being integrated into modern health care. In cirrhosis, uptake and adoption of these practices have been limited with physicians citing many perceived barriers and limitations. Recognizing the many tangible benefits of ACP and GCD processes in patients with life‐limiting chronic diseases, the onus is on health practitioners to initiate and direct these conversations with their patients and surrogates.

Advance care planning (ACP) for specialists managing cirrhosis: A focus on patient‐centered care

Amanda Brisebois, Kathleen P. Ismond, Michelle Carbonneau, Jan Kowalczewski, Puneeta Tandon – 18 December 2017 – Advance care planning (ACP) and goals of care designation (GCD) are being integrated into modern health care. In cirrhosis, uptake and adoption of these practices have been limited with physicians citing many perceived barriers and limitations. Recognizing the many tangible benefits of ACP and GCD processes in patients with life‐limiting chronic diseases, the onus is on health practitioners to initiate and direct these conversations with their patients and surrogates.

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