Identification and Therapeutic Intervention of Coactivated Anaplastic Lymphoma Kinase, Fibroblast Growth Factor Receptor 2, and Ephrin Type‐A Receptor 5 Kinases in Hepatocellular Carcinoma
Xin Wang, Minmin Zhang, Fangfang Ping, Hongchun Liu, Jingya Sun, Yueqin Wang, Aijun Shen, Jian Ding, Meiyu Geng – 21 January 2018 – Though kinase inhibitors have been heavily investigated in the clinic to combat advanced hepatocellular carcinoma (HCC), clinical outcomes have been disappointing overall, which may be due to the absence of kinase‐addicted subsets in HCC patients. Recently, strategies that simultaneously inhibit multiple kinases are increasingly appreciated in HCC treatment, yet they are challenged by the dynamic nature of the kinase networks.
Cyclophilin D deficiency attenuates mitochondrial perturbation and ameliorates hepatic steatosis
Xiaolei Wang, Heng Du, Shanshan Shao, Tao Bo, Chunxiao Yu, Wenbin Chen, Lifang Zhao, Qiu Li, Li Wang, Xiaojing Liu, Xiaohui Su, Mingqi Sun, Yongfeng Song, Ling Gao, Jiajun Zhao – 21 January 2018 – Physiological opening of the mitochondrial permeability transition pore (mPTP) is indispensable for maintaining mitochondrial function and cell homeostasis, but the role of the mPTP and its initial factor, cyclophilin D (CypD), in hepatic steatosis is unclear. Here, we demonstrate that excess mPTP opening is mediated by an increase of CypD expression induced hepatic mitochondrial dysfunction.
Hepatitis B virus surface gene pre‐S2 mutant as a high‐risk serum marker for hepatoma recurrence after curative hepatic resection
Chia‐Jui Yen, Yu‐Lin Ai, Hung‐Wen Tsai, Shih‐Huang Chan, Chia‐Sheng Yen, Kuang‐Hsiung Cheng, Yun‐Ping Lee, Chia‐Wei Kao, Yu‐Chun Wang, Yi‐Lin Chen, Cheng‐Han Lin, Tsunglin Liu, Huey‐Pin Tsai, Jen‐Ren Wang, Ih‐Jen Su, Wenya Huang – 19 January 2018 – Chronic hepatitis B virus (HBV) infection is the major cause of hepatocellular carcinoma (HCC). The pre‐S2 mutant large HBV surface antigen (LHBS) is highly associated with HCC.
Heparin but not tissue plasminogen activator improves outcomes in donation after circulatory death liver transplantation in a porcine model
Amelia J. Hessheimer, Marina Vendrell, Javier Muñoz, Ángel Ruíz, Alba Díaz, Luís Flores Sigüenza, Jorge Rodríguez Lanzilotta, Eduardo Delgado Oliver, Jose Fuster, Miquel Navasa, Juan Carlos García‐Valdecasas, Pilar Taurá, Constantino Fondevila – 19 January 2018 – Ischemic‐type biliary lesions (ITBLs) arise most frequently after donation after circulatory death (DCD) liver transplantation and result in high morbidity and graft loss. Many DCD grafts are discarded out of fear for this complication.
Avoid rejecting livers from donation after circulatory death donors based on donor age alone
David P. Foley – 19 January 2018
Randomized trial on extended versus modified right lobe grafts in living donor liver transplantation
Christi Titus Varghese, Viju Kumar Bharathan, Unnikrishnan Gopalakrishnan, Dinesh Balakrishnan, Ramachandran N. Menon, Othiyil Vayoth Sudheer, Puneet Dhar, Surendran Sudhindran – 19 January 2018 – Despite advances in the practice of living donor liver transplantation (LDLT), the optimum surgical approach with respect to the middle hepatic vein (MHV) in right lobe LDLT remains undefined.
A novel technique for collateral interruption to maximize portal venous flow in pediatric liver transplantation
Seisuke Sakamoto, Kengo Sasaki, Toshihiro Kitajima, Yoshihiro Hirata, Soichi Narumoto, Kourosh Kazemi, Akinari Fukuda, Osamu Miyazaki, Shunsuke Nosaka, Mureo Kasahara – 19 January 2018
Living donor liver transplantation for hepatocellular carcinoma: To expand (beyond Milan) or downstage (to Milan)?
Neil Mehta, Francis Y. Yao – 19 January 2018
Diet affects gut microbiota and modulates hospitalization risk differentially in an international cirrhosis cohort
Jasmohan S. Bajaj, Ramazan Idilman, Leila Mabudian, Matthew Hood, Andrew Fagan, Dilara Turan, Melanie B. White, Fatih Karakaya, Jessica Wang, Rengül Atalay, Phillip B. Hylemon, Edith A. Gavis, Robert Brown, Leroy R. Thacker, Chathur Acharya, Douglas M. Heuman, Masoumeh Sikaroodi, Patrick M. Gillevet – 19 January 2018 – The relative ranking of cirrhosis‐related deaths differs between high‐/middle‐income countries. Gut microbiome is affected in cirrhosis and is related to diet. Our aim was to determine the effect of differing dietary habits on gut microbiota and clinical outcomes.