Increased expression of GATA zinc finger domain containing 1 through gene amplification promotes liver cancer by directly inducing phosphatase of regenerating liver 3

Wei Sun, Yanquan Zhang, Ka Chun Wong, Ken Liu, Yidong Yang, Bin Wu, Joanna H.M. Tong, Anthony W.H. Chan, Henry L.Y. Chan, Jun Yu – 21 December 2017 – We identified that GATA zinc finger domain containing 1 (GATAD1), a transcriptional factor, was significantly up‐regulated in hepatocellular carcinoma (HCC) through gene amplification. We demonstrated the critical role, molecular mechanisms, and clinical implications of GATAD1 as a novel oncogenic factor in HCC. We found that GATAD1 protein was expressed in 76.6% of primary HCCs (85/111) but silenced in normal liver tissues.

Ligation versus no ligation of spontaneous portosystemic shunts during liver transplantation: Audit of a prospective series of 66 consecutive patients

Concepcion Gomez Gavara, Prashant Bhangui, Chady Salloum, Michael Osseis, Francesco Esposito, Toufic Moussallem, Eylon Lahat, Liliana Fuentes, Philippe Compagnon, Norbert Ngongang, Chetana Lim, Daniel Azoulay – 21 December 2017 – The management of large spontaneous portosystemic shunt (SPSS) during liver transplantation (LT) is a matter of debate. The aim of this study is to compare the short‐term and longterm outcomes of SPSS ligation versus nonligation during LT, when both options are available.

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