MAIT cells are chronically activated in patients with autoimmune liver disease and promote profibrogenic hepatic stellate cell activation

Katrin Böttcher, Krista Rombouts, Francesca Saffioti, Davide Roccarina, Matteo Rosselli, Andrew Hall, TuVinh Luong, Emmanuel A. Tsochatzis, Douglas Thorburn, Massimo Pinzani – 12 January 2018 – Autoimmune liver diseases (AILDs) are chronic liver pathologies characterized by fibrosis and cirrhosis due to immune‐mediated liver damage.

Serologic responses and effectiveness of hepatitis A vaccination among human immunodeficiency virus–positive individuals during the outbreak of acute hepatitis A

Kuan‐Yin Lin, Szu‐Min Hsieh, Hsin‐Yun Sun, Yi‐Chun Lo, Wang‐Huei Sheng, Yu‐Chung Chuang, Aristine Cheng, Sung‐Ching Pan, Guan‐Jhou Chen, Chien‐Ching Hung, Shan‐Chwen Chang – 12 January 2018 – Outbreaks of hepatitis A virus (HAV) infection have been occurring among men who have sex with men in the Asia‐Pacific region, the United States, and several European countries since June 2015 and recently among persons who are homeless and use illicit drugs in the United States.

Hepatocellular carcinoma–related cyclin D1 is selectively regulated by autophagy degradation system

Shan‐Ying Wu, Sheng‐Hui Lan, Shang‐Rung Wu, Yen‐Chi Chiu, Xi‐Zhang Lin, Ih‐Jen Su, Ting‐Fen Tsai, Chia‐Jui Yen, Tsung‐Hsueh Lu, Fu‐Wen Liang, Chung‐Yi Li, Huey‐Jen Su, Chun‐Li Su, Hsiao‐Sheng Liu – 12 January 2018 – Dysfunction of degradation machineries causes cancers, including hepatocellular carcinoma (HCC). Overexpression of cyclin D1 in HCC has been reported. We previously reported that autophagy preferentially recruits and degrades the oncogenic microRNA (miR)‐224 to prevent HCC.

Coronary artery disease in decompensated patients undergoing liver transplantation evaluation

Samarth S. Patel, Eiman Nabi, Luis Guzman, Antonio Abbate, Chandra Bhati, Richard T. Stravitz, Trevor Reichman, Scott C. Matherly, Carolyn Driscoll, Hannah Lee, Velimir A. Luketic, Richard K. Sterling, Arun J. Sanyal, Vaishali Patel, Marlon Levy, Mohammad Shadab Siddiqui – 12 January 2018 – Coronary artery disease (CAD) is an important contributor to morbidity and mortality in patients undergoing liver transplantation (LT). However, the current literature is limited by sampling bias and nondefinitive assessment of CAD.

Improved portal vein venoplasty with an autogenous patch in pediatric living donor liver transplantation

Mingxuan Feng, Ping Wan, Bijun Qiu, Tao Zhou, Yi Luo, Lihong Gu, Jiachang Chi, Chengpeng Zhong, Yefeng Lu, Jianjun Zhang, Qiang Xia – 12 January 2018 – A stenotic or hypoplastic portal vein (PV) represents a challenge for PV reconstruction in pediatric living donor liver transplantation (LDLT). Several PV venoplastic techniques have been developed. However, we still seek improved venoplastic techniques with better efficacy and compatibility. From June 2016 to July 2017, 271 LDLT procedures were performed at the Department of Liver Surgery, Renji Hospital.

Can genetic testing guide the therapy of cholestatic pruritus? A case of benign recurrent intrahepatic cholestasis type 2 with severe nasobiliary drainage‐refractory itch

Robert Holz, Andreas E. Kremer, Dieter Lütjohann, Hermann E. Wasmuth, Frank Lammert, Marcin Krawczyk – 10 January 2018 – Benign recurrent intrahepatic cholestasis (BRIC) is a peculiar familial disease caused by mutations of the genes encoding hepatocanalicular flippase for phosphatidylserine (ATP8B1; BRIC type 1) or the bile salt export pump (ABCB11; BRIC type 2). Here, we report on a patient with nasobiliary drainage‐refractory BRIC type 2 who improved under plasma separation and anion absorption therapy.

Offer acceptance practices and geographic variability in allocation model for end‐stage liver disease at transplant

Andrew Wey, Joshua Pyke, David P. Schladt, Sommer E. Gentry, Tim Weaver, Nicholas Salkowski, Bertram L. Kasiske, Ajay K. Israni, Jon J. Snyder – 9 January 2018 – Offer acceptance practices may cause geographic variability in allocation Model for End‐Stage Liver Disease (aMELD) score at transplant and could magnify the effect of donor supply and demand on aMELD variability.

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