Acute decompensation boosts hepatic collagen type III deposition and deteriorates experimental and human cirrhosis

Michael Praktiknjo, Jennifer Lehmann, Mette J. Nielsen, Robert Schierwagen, Frank E. Uschner, Carsten Meyer, Daniel Thomas, Christian P. Strassburg, Flemming Bendtsen, Søren Møller, Aleksander Krag, Morten A. Karsdal, Diana J. Leeming, Jonel Trebicka – 18 January 2018 – Patients with end‐stage liver disease develop acute decompensation (AD) episodes, which become more frequent and might develop into acute‐on‐chronic liver failure (ACLF). However, it remains unknown how AD induces acceleration of liver disease.

Incidence and cost analysis of hospital admission and 30‐day readmission among patients with cirrhosis

Sakkarin Chirapongsathorn, Chayakrit Krittanawong, Felicity T. Enders, Richard Pendegraft, Kristin C. Mara, Bijan J. Borah, Sue L. Visscher, Conor G. Loftus, Vijay H. Shah, Jayant A. Talwalkar, Patrick S. Kamath – 18 January 2018 – We examined risks for first hospitalization and the rate, risk factors, costs, and 1‐year outcome of 30‐day readmission among patients admitted for complications of cirrhosis.

What are the outcomes of declining a public health service increased risk liver donor for patients on the liver transplant waiting list?

Kristopher P. Croome, David D. Lee, Surakit Pungpapong, Andrew P. Keaveny, C. Burcin Taner – 17 January 2018 – The tragedy of the national opioid epidemic has resulted in a significant increase in the number of opioid‐related deaths and accordingly an increase in the number of potential donors designated Public Health Service (PHS) increased risk. Previous studies have demonstrated reluctance to use these PHS organs, and as a result, higher discard rates for these organs have been observed.

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