Liver‐specific deficiency of unc‐51 like kinase 1 and 2 protects mice from acetaminophen‐induced liver injury

Yu Sun, Terytty Yang Li, Lintao Song, Cixiong Zhang, Jingyi Li, Zhi‐Zhong Lin, Sheng‐Cai Lin, Shu‐Yong Lin – 22 December 2017 – unc‐51‐like autophagy activating kinase 1 and 2 (Ulk1/2) regulate autophagy initiation under various stress conditions. However, the physiological functions of these Ser/Thr kinases are not well characterized. Here, we show that mice with liver‐specific double knockout (LDKO) of Ulk1 and Ulk2 (Ulk1/2 LDKO) are viable, but exhibit overt hepatomegaly phenotype.

Patient‐reported outcomes in cirrhosis: A scoping review of the literature

Elliot B. Tapper, Fasiha Kanwal, Sumeet K. Asrani, Chanda Ho, Nadia Ovchinsky, John Poterucha, Avegail Flores, Judith E. Smith, Victor Ankoma‐Sey, Bruce Luxon, Michael L. Volk – 22 December 2017 – Patients with cirrhosis seek improvement in their symptoms, functioning, quality of life, and satisfaction with the care they receive. However, these patient‐reported outcomes (PROs) are not routinely measured for clinical care, research, or quality improvement.

Ligation versus no ligation of spontaneous portosystemic shunts during liver transplantation: Audit of a prospective series of 66 consecutive patients

Concepcion Gomez Gavara, Prashant Bhangui, Chady Salloum, Michael Osseis, Francesco Esposito, Toufic Moussallem, Eylon Lahat, Liliana Fuentes, Philippe Compagnon, Norbert Ngongang, Chetana Lim, Daniel Azoulay – 21 December 2017 – The management of large spontaneous portosystemic shunt (SPSS) during liver transplantation (LT) is a matter of debate. The aim of this study is to compare the short‐term and longterm outcomes of SPSS ligation versus nonligation during LT, when both options are available.

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