Natural history of nonalcoholic fatty liver disease: A prospective follow‐up study with serial biopsies

Patrik Nasr, Simone Ignatova, Stergios Kechagias, Mattias Ekstedt – 27 December 2017 – Nonalcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease in the world. The complete natural history of NAFLD is unknown because few high‐quality follow‐up studies have been conducted. Our aim was to find variables predicting disease severity through an extended follow‐up with serial biopsies.

Macrotrabecular‐massive hepatocellular carcinoma: A distinctive histological subtype with clinical relevance

Marianne Ziol, Nicolas Poté, Giuliana Amaddeo, Alexis Laurent, Jean‐Charles Nault, Frédéric Oberti, Charlotte Costentin, Sophie Michalak, Mohamed Bouattour, Claire Francoz, Georges Philippe Pageaux, Jeanne Ramos, Thomas Decaens, Alain Luciani, Boris Guiu, Valérie Vilgrain, Christophe Aubé, Jonathan Derman, Cécile Charpy, Jessica Zucman‐Rossi, Nathalie Barget, Olivier Seror, Nathalie Ganne‐Carrié, Valérie Paradis, Julien Calderaro – 27 December 2017 – We recently identified a histological subtype of hepatocellular carcinoma (HCC), designated as “macrotrabecular‐massive” (MTM‐HCC) and associa

Normothermic machine perfusion of donor livers without the need for human blood products

Alix P. M. Matton, Laura C. Burlage, Rianne van Rijn, Yvonne de Vries, Shanice A. Karangwa, Maarten W. Nijsten, Annette S. H. Gouw, Janneke Wiersema‐Buist, Jelle Adelmeijer, Andrie C. Westerkamp, Ton Lisman, Robert J. Porte – 27 December 2017 – Normothermic machine perfusion (NMP) enables viability assessment of donor livers prior to transplantation. NMP is frequently performed by using human blood products including red blood cells (RBCs) and fresh frozen plasma (FFP).

Natural history of nonalcoholic fatty liver disease: A prospective follow‐up study with serial biopsies

Patrik Nasr, Simone Ignatova, Stergios Kechagias, Mattias Ekstedt – 27 December 2017 – Nonalcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease in the world. The complete natural history of NAFLD is unknown because few high‐quality follow‐up studies have been conducted. Our aim was to find variables predicting disease severity through an extended follow‐up with serial biopsies.

Genomic perturbations reveal distinct regulatory networks in intrahepatic cholangiocarcinoma

Chirag Nepal, Colm J. O'Rourke, Douglas V.N.P. Oliveira, Andrzej Taranta, Steven Shema, Prson Gautam, Julien Calderaro, Andrew Barbour, Chiara Raggi, Krister Wennerberg, Xin W. Wang, Anja Lautem, Lewis R. Roberts, Jesper B. Andersen – 26 December 2017 – Intrahepatic cholangiocarcinoma remains a highly heterogeneous malignancy that has eluded effective patient stratification to date. The extent to which such heterogeneity can be influenced by individual driver mutations remains to be evaluated.

Outcomes after multiple courses of granulocyte colony‐stimulating factor and growth hormone in decompensated cirrhosis: A randomized trial

Nipun Verma, Amritjyot Kaur, Ratiram Sharma, Ashish Bhalla, Navneet Sharma, Arka De, Virendra Singh – 26 December 2017 – Decompensated cirrhosis (DC) carries a high mortality. Liver transplantation (LT) is the treatment of choice; however, the limited availability of donor organs has resulted in high waitlist mortality. The present study investigated the impact of multiple courses of granulocyte‐colony stimulating factor (G‐CSF) with or without growth hormone (GH) in these patients.

Hypothermic machine perfusion in liver transplantation

R. Cutler Quillin, James V. Guarrera – 26 December 2017 – A finite supply of donor organs has led many transplant centers to accept marginal liver allografts with increasing frequency. These allografts may be at higher risk of primary nonfunction, early allograft dysfunction, and other recipient complications following liver transplantation. Machine perfusion preservation is an emerging technology that limits ischemia/reperfusion injury associated with preservation and may lead to improved outcomes following transplantation.

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