Surveillance for hepatobiliary cancers in patients with primary sclerosing cholangitis

Ahmad Hassan Ali, James H. Tabibian, Navine Nasser‐Ghodsi, Ryan J. Lennon, Thomas DeLeon, Mitesh J. Borad, Moira Hilscher, Marina G. Silveira, Elizabeth J. Carey, Keith D. Lindor – 15 December 2017 – Primary sclerosing cholangitis (PSC) is a risk factor for cholangiocarcinoma (CCA) and gallbladder carcinoma (GBCa). Surveillance for GBCa is recommended, but the clinical utility of surveillance for other hepatobiliary cancers (HBCa) in PSC, namely CCA and hepatocellular carcinoma (HCC), remains unclear.

Current and future therapeutic regimens for nonalcoholic fatty liver disease and nonalcoholic steatohepatitis

Zobair M. Younossi, Rohit Loomba, Mary E. Rinella, Elisabetta Bugianesi, Giulio Marchesini, Brent A. Neuschwander‐Tetri, Lawrence Serfaty, Francesco Negro, Stephen H. Caldwell, Vlad Ratziu, Kathleen E. Corey, Scott L. Friedman, Manal F. Abdelmalek, Stephen A. Harrison, Arun J. Sanyal, Joel E. Lavine, Philippe Mathurin, Michael R. Charlton, Naga P. Chalasani, Quentin M. Anstee, Kris V. Kowdley, Jacob George, Zachary D.

Fibrolamellar carcinoma in the Carney complex: PRKAR1A loss instead of the classic DNAJB1‐PRKACA fusion

Rondell P. Graham, Carolin Lackner, Luigi Terracciano, Yessica González‐Cantú, Joseph J. Maleszewski, Patricia T. Greipp, Sanford M. Simon, Michael S. Torbenson – 9 December 2017 – Fibrolamellar carcinomas are characterized by activation of protein kinase A, a kinase composed of catalytic and regulatory subunits. PRKACA encodes a catalytic subunit of protein kinase A, and almost all fibrolamellar carcinomas have a heterozygous 400‐kb deletion that leads to the fusion of DNAJB1 and PRKACA.

Survival of children after liver transplantation for hepatocellular carcinoma

Ulrich Baumann, René Adam, Christophe Duvoux, Rafael Mikolajczyk, Vincent Karam, Lorenzo D'Antiga, Christophe Chardot, Ahmet Coker, Michele Colledan, Bo‐Goran Ericzon, Pål Dag Line, Nedim Hadzic, Helena Isoniemi, Jürgen L. Klempnauer, Raymond Reding, Patrick J. McKiernan, Valérie McLin, Andreas Paul, Mauro Salizzoni, Emanuel San Bento Furtado, Stefan Schneeberger, André Karch, for the European Liver and Intestine Transplant Association – 9 December 2017 – Hepatocellular carcinoma (HCC) in childhood differs from adult HCC because it is often associated with inherited liver disease.

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