The short‐term incidence of hepatocellular carcinoma is not increased after hepatitis C treatment with direct‐acting antivirals: An ERCHIVES study

Darrick K. Li, Yanjie Ren, Daniel S. Fierer, Stephanie Rutledge, Obaid S. Shaikh, Vincent Lo Re, Tracey Simon, Abdul‐Badi Abou‐Samra, Raymond T. Chung, Adeel A. Butt – 2 December 2017 – Recent studies have reported higher rates of hepatocellular carcinoma (HCC) in individuals treated with direct‐acting antivirals (DAAs). However, making definitive conclusions has been challenging because of the heterogeneous populations and methodologies of these reports.

Thoracic epidural analgesia in donor hepatectomy: An analysis

Archna Koul, Deepanjali Pant, Swetha Rudravaram, Jayashree Sood – 2 December 2017 – The purpose of this study is to analyze whether supplementation of general anesthesia (GA) with thoracic epidural analgesia (TEA) for right lobe donor hepatectomy is a safe modality of pain relief in terms of changes in postoperative coagulation profile, incidence of epidural catheter–related complications, and timing of removal of epidural catheter. Retrospective analysis of the record of 104 patients who received TEA for right lobe donor hepatectomy was done.

Standardized hybrid living donor hemihepatectomy in adult‐to‐adult living donor liver transplantation

Susumu Eguchi, Akihiko Soyama, Takanobu Hara, Koji Natsuda, Satomi Okada, Takashi Hamada, Taiichiro Kosaka, Shinichiro Ono, Tomohiko Adachi, Masaaki Hidaka, Mitsuhisa Takatsuki – 1 December 2017 – The aim of this study was to analyze the outcomes of the most updated version and largest group of our standardized hybrid (laparoscopic mobilization and hepatectomy through midline incision) living donor (LD) hemihepatectomy compared with those from a conventional laparotomy in adult‐to‐adult living donor liver transplantation (LDLT).

The RNA genome of hepatitis E virus robustly triggers an antiviral interferon response

Wenshi Wang, Yijin Wang, Changbo Qu, Shan Wang, Jianhua Zhou, Wanlu Cao, Lei Xu, Buyun Ma, Mohamad S. Hakim, Yuebang Yin, Tiancheng Li, Maikel P. Peppelenbosch, Jingmin Zhao, Qiuwei Pan – 1 December 2017 – The outcomes of hepatitis E virus (HEV) infection are diverse, ranging from asymptomatic carrier, self‐limiting acute infection, and fulminant hepatitis to persistent infection. This is closely associated with the immunological status of the host. This study aimed to understand the innate cellular immunity as the first‐line defense mechanism in response to HEV infection.

Bleeding complications in acute liver failure

R. Todd Stravitz, Caitlyn Ellerbe, Valerie Durkalski, Michael Schilsky, Robert J. Fontana, Carolyn Peterseim, William M. Lee, and the Acute Liver Failure Study Group – 1 December 2017 – In patients with acute liver failure (ALF), elevated prothrombin time and thrombocytopenia can fuel a perception of a bleeding tendency. However, the incidence, site, risk factors, and clinical significance of bleeding complications have not been quantified in a large cohort of patients with ALF. We studied 1,770 adult patients enrolled in the ALF Study Group Registry between 1998 and 2016.

Impact of hepatitis C virus polymorphisms on direct‐acting antiviral treatment efficacy: Regulatory analyses and perspectives

Patrick R. Harrington, Takashi E. Komatsu, Damon J. Deming, Eric F. Donaldson, Julian J. O'Rear, Lisa K. Naeger – 1 December 2017 – Several highly effective, interferon‐free, direct‐acting antiviral (DAA)‐based regimens are available for the treatment of chronic hepatitis C virus (HCV) infection. Despite impressive efficacy overall, a small proportion of patients in registrational trials experienced treatment failure, which in some cases was associated with the detection of HCV resistance‐associated substitutions (RASs) at baseline.

Subscribe to