Stereotactic ablative radiotherapy for hepatocellular carcinoma: History, current status, and opportunities

Jeffrey Meyer, Amit G. Singal – 5 December 2017 – A variety of surgical and other local‐regional approaches to the management of hepatocellular carcinoma (HCC) are in clinical use. External beam radiation therapy is a relative newcomer to the portfolio of treatment options. Advances in planning and delivery of radiation therapy, developing in parallel with and inspiring changing paradigms of tumor management in the field of radiation oncology, have led to growing interest in radiation therapy as a viable treatment option for HCC as well as other liver tumors.

Prediction of histologic alcoholic hepatitis based on clinical presentation limits the need for liver biopsy

Nitzan C. Roth, Behnam Saberi, Jared Macklin, Gary Kanel, Samuel W. French, Sugantha Govindarajan, Anthony S. Buzzanco, Andrew A. Stolz, John A. Donovan, Neil Kaplowitz – 4 December 2017 – The clinical presentation of alcoholic hepatitis (AH) can be mimicked by other alcoholic liver diseases. The aim of this study was to identify clinical features that predict AH on liver biopsy. Biopsies from patients hospitalized for presumed severe AH were used to identify a derivation cohort (101 patients) and validation cohort (71 patients).

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Behnam Saberi, Alia S. Dadabhai, Christine M. Durand, Benjamin Philosophe, Andrew M. Cameron, Mark S. Sulkowski, Ahmet Gurakar – 2 December 2017

Hepatitis C transmission from seropositive, nonviremic donors to non–hepatitis C liver transplant recipients

Khurram Bari, Keith Luckett, Tiffany Kaiser, Tayyab Diwan, Madison Cuffy, Michael R. Schoech, Kamran Safdar, Jason T. Blackard, Senu Apewokin, Flavio Paterno, Kenneth E. Sherman, Stephen D. Zucker, Nadeem Anwar, Shimul A. Shah – 2 December 2017 – Breakthroughs in hepatitis C virus (HCV) treatment and rising rates of intravenous drug use have led to an increase in the number of organ donors who are HCV antibody–positive but serum nucleic acid test (NAT)–negative. The risk of HCV transmission from the liver grafts of these donors to recipients is unknown.

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