Decellularized human placenta supports hepatic tissue and allows rescue in acute liver failure

Zurab Kakabadze, Ann Kakabadze, David Chakhunashvili, Lia Karalashvili, Ekaterine Berishvili, Yogeshwar Sharma, Sanjeev Gupta – 6 December 2017 – Tissue engineering with scaffolds to form transplantable organs is of wide interest. Decellularized tissues have been tested for this purpose, although supplies of healthy donor tissues, vascular recellularization for perfusion, and tissue homeostasis in engineered organs pose challenges. We hypothesized that decellularized human placenta will be suitable for tissue engineering.

Impact of aberrant left hepatic artery ligation on the outcome of liver transplantation

Roberto Montalti, Andrea Benedetti Cacciaguerra, Daniele Nicolini, Emad Alì Ahmed, Martina Coletta, Lesley De Pietri, Andrea Risaliti, Roberto Ivan Troisi, Federico Mocchegiani, Marco Vivarelli – 6 December 2017 – The preservation of a graft's aberrant left hepatic artery (LHA) during liver transplantation (LT) ensures optimal vascularization of the left liver but can also be considered a risk factor for hepatic artery thrombosis (HAT). In contrast, ligation of an aberrant LHA may lead to hepatic ischemia with the potential risk of graft dysfunction and biliary complications.

Stereotactic ablative radiotherapy for hepatocellular carcinoma: History, current status, and opportunities

Jeffrey Meyer, Amit G. Singal – 5 December 2017 – A variety of surgical and other local‐regional approaches to the management of hepatocellular carcinoma (HCC) are in clinical use. External beam radiation therapy is a relative newcomer to the portfolio of treatment options. Advances in planning and delivery of radiation therapy, developing in parallel with and inspiring changing paradigms of tumor management in the field of radiation oncology, have led to growing interest in radiation therapy as a viable treatment option for HCC as well as other liver tumors.

Prediction of histologic alcoholic hepatitis based on clinical presentation limits the need for liver biopsy

Nitzan C. Roth, Behnam Saberi, Jared Macklin, Gary Kanel, Samuel W. French, Sugantha Govindarajan, Anthony S. Buzzanco, Andrew A. Stolz, John A. Donovan, Neil Kaplowitz – 4 December 2017 – The clinical presentation of alcoholic hepatitis (AH) can be mimicked by other alcoholic liver diseases. The aim of this study was to identify clinical features that predict AH on liver biopsy. Biopsies from patients hospitalized for presumed severe AH were used to identify a derivation cohort (101 patients) and validation cohort (71 patients).

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