Microbiota and the liver

Ting‐Chin David Shen, Nikolaos Pyrsopoulos, Vinod K. Rustgi – 6 January 2018 – The gut microbiome outnumbers the human genome by 150‐fold and plays important roles in metabolism, immune system education, tolerance development, and prevention of pathogen colonization. Dysbiosis has been associated with nonalcoholic fatty liver disease (NAFLD), nonalcoholic steatohepatitis (NASH), and alcoholic liver disease (ALD) as well as cirrhosis and complications. This article provides an overview of this relationship. Liver Transplantation 24 539–550 2018 AASLD.

Patterning of the hepato‐pancreatobiliary boundary by BMP reveals heterogeneity within the murine liver bud

Amrita Palaria, Jesse R. Angelo, Taylor M. Guertin, Jesse Mager, Kimberly D. Tremblay – 5 January 2018 – During development, the endoderm initiates organ‐restricted gene expression patterns in a spatiotemporally controlled manner. This process, termed induction, requires signals from adjacent mesodermal derivatives.

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