Exosome miR‐335 as a novel therapeutic strategy in hepatocellular carcinoma
Fang Wang, Ling Li, Klaus Piontek, Masazumi Sakaguchi, Florin M. Selaru – 10 October 2017 – Hepatocellular carcinoma (HCC) is a common and deadly cancer. Most cases of HCC arise in a cirrhotic/fibrotic liver, indicating that environment may play a paramount role in cancer genesis. Previous studies from our group and others have shown that, in desmoplastic cancers, there is a rich intercellular communication between activated, cancer‐associated fibroblasts and cancer cells.