Exosome miR‐335 as a novel therapeutic strategy in hepatocellular carcinoma

Fang Wang, Ling Li, Klaus Piontek, Masazumi Sakaguchi, Florin M. Selaru – 10 October 2017 – Hepatocellular carcinoma (HCC) is a common and deadly cancer. Most cases of HCC arise in a cirrhotic/fibrotic liver, indicating that environment may play a paramount role in cancer genesis. Previous studies from our group and others have shown that, in desmoplastic cancers, there is a rich intercellular communication between activated, cancer‐associated fibroblasts and cancer cells.

Combined liver‐kidney perfusion enhances protective effects of normothermic perfusion on liver grafts from donation after cardiac death

Xiaoshun He, Fei Ji, Zhiheng Zhang, Yunhua Tang, Lu Yang, Shanzhou Huang, Wenwen Li, Qiao Su, Wei Xiong, Zebin Zhu, Linhe Wang, Lei Lv, Jiyou Yao, Linan Zhang, Longjuan Zhang, Zhiyong Guo – 10 October 2017 – It has been shown that combined liver‐kidney normothermic machine perfusion (NMP) is able to better maintain the circuit's biochemical milieu. Nevertheless, whether the combined perfusion is superior to liver perfusion alone in protecting livers from donation after circulatory death (DCD) is unclear. We aimed to test the hypothesis and explored the mechanisms.

Genetic diversity and worldwide distribution of the deltavirus genus: A study of 2,152 clinical strains

Frédéric Le Gal, Ségolène Brichler, Tudor Drugan, Chakib Alloui, Dominique Roulot, Jean‐Michel Pawlotsky, Paul Dény, Emmanuel Gordien – 9 October 2017 – Hepatitis delta virus (HDV) is responsible for the most severe form of acute and chronic viral hepatitis. We previously proposed that the Deltavirus genus is composed of eight major clades. However, few sequences were available to confirm this classification. Moreover, little is known about the structural and functional consequences of HDV variability.

Role of aramchol in steatohepatitis and fibrosis in mice

Marta Iruarrizaga‐Lejarreta, Marta Varela‐Rey, David Fernández‐Ramos, Ibon Martínez‐Arranz, Teresa C Delgado, Jorge Simon, Virginia Gutiérrez‐de Juan, Laura delaCruz‐Villar, Mikel Azkargorta, José L. Lavin, Rebeca Mayo, Sebastiaan M. Van Liempd, Igor Aurrekoetxea, Xabier Buqué, Donatella Delle Cave, Arantza Peña, Juan Rodríguez‐Cuesta, Ana M. Aransay, Felix Elortza, Juan M. Falcón‐Pérez, Patricia Aspichueta, Liat Hayardeny, Mazen Noureddin, Arun J. Sanyal, Cristina Alonso, Juan Anguita, María Luz Martínez‐Chantar, Shelly C. Lu, José M.

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