Is mIndy a mediator of energy metabolism reprogramming in hepatocellular carcinoma induced by interleukin‐6/signal transducer and activator of transcription 3 signaling?
Yan Chen, Zhen Zeng, Yinying Lu – 12 October 2017
Impact of surveillance for hepatocellular carcinoma on survival in patients with compensated cirrhosis
Ju Dong Yang, Ajitha Mannalithara, Andrew J. Piscitello, John B. Kisiel, Gregory J. Gores, Lewis R. Roberts, W. Ray Kim – 12 October 2017 – Surveillance for hepatocellular carcinoma (HCC) has been recommended in patients with cirrhosis. In this study, we examined the extent to which the competing risk of hepatic decompensation influences the benefit of HCC surveillance by investigating the impact of availability of liver transplantation (LTx) and the rate of progression of hepatic decompensation on survival gain from HCC surveillance.
Generation of safe and therapeutically effective human induced pluripotent stem cell‐derived hepatocyte‐like cells for regenerative medicine
Kazuo Takayama, Naoki Akita, Natsumi Mimura, Rina Akahira, Yukimasa Taniguchi, Makoto Ikeda, Fuminori Sakurai, Osamu Ohara, Tomohiro Morio, Kiyotoshi Sekiguchi, Hiroyuki Mizuguchi – 12 October 2017 – Hepatocyte‐like cells (HLCs) differentiated from human induced pluripotent stem (iPS) cells are expected to be applied for regenerative medicine. In this study, we attempted to generate safe and therapeutically effective human iPS‐HLCs for hepatocyte transplantation.
Radioembolization for hepatocellular carcinoma: The time has come
Beau Toskich, Tushar Patel – 12 October 2017
Myeloid Notch1 deficiency activates the RhoA/ROCK pathway and aggravates hepatocellular damage in mouse ischemic livers
Ling Lu, Shi Yue, Longfeng Jiang, Changyong Li, Qiang Zhu, Michael Ke, Hao Lu, Xuehao Wang, Ronald W. Busuttil, Qi‐Long Ying, Jerzy W. Kupiec‐Weglinski, Bibo Ke – 12 October 2017 – Notch signaling plays an emerging role in the regulation of immune cell development and function during inflammatory response. Activation of the ras homolog gene family member A/Rho‐associated protein kinase (ROCK) pathway promotes leukocyte accumulation in tissue injury.
Erratum: Reassessing the Safety Concerns of Utilizing Blood Donations from Patients with Hemochromatosis
Adam C. Winters, Douglas Tremblay, Suzanne Arinsburg, John Mascarenhas, Thomas D. Schiano – 12 October 2017 – After publication of our manuscript, it came to our attention that the Australian Red Cross does indeed accept blood donations from patient with hemochromatosis (HH).
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Christian von Loeffelholz, Andreas L. Birkenfeld – 12 October 2017
Longterm outcome of rendezvous technique for hepaticojejunal anastomotic obstruction after pediatric living donor liver transplantation
Yukihiro Sanada, Tomonori Yano, Taizen Urahashi, Yoshiyuki Ihara, Noriki Okada, Naoya Yamada, Yuta Hirata, Takumi Katano, Hironori Yamamoto, Koichi Mizuta – 12 October 2017
Current status of liver transplantation for cholangiocarcinoma
Nicolás Goldaracena, Andre Gorgen, Gonzalo Sapisochin – 11 October 2017 – Cholangiocarcinoma (CCA) is the second most common liver cancer, and it is associated with a poor prognosis. CCA can be divided into intrahepatic, hilar, and distal. Despite the subtype, the median survival is 12‐24 months without treatment. Liver transplantation (LT) is recognized worldwide as a curative option for hepatocellular carcinoma. On the other hand, the initial results for LT for CCA were very poor mainly due to a lack of adequate patient selection.
Risk of posttransplant hepatocellular carcinoma recurrence is greater in recipients with higher platelet counts in living donor liver transplantation
Sangbin Han, Sanghoon Lee, Ju Dong Yang, Michael Douglas Leise, Joong Hyun Ahn, Seonwoo Kim, Kangha Jung, Mi Sook Gwak, Gaab Soo Kim, Justin Sangwook Ko – 11 October 2017 – Platelets interact with tumor cells and promote metastasis. The importance of platelets in posttransplant hepatocellular carcinoma (HCC) recurrence is unclear. Thus, we aimed to evaluate the association between preoperative platelet count (PLT) and HCC recurrence after living donor liver transplantation.