Distinct role of nuclear receptor corepressor 1 regulated de novo fatty acids synthesis in liver regeneration and hepatocarcinogenesis in mice

Qing Ou‐Yang, Xi‐Meng Lin, Yan‐Jing Zhu, Bo Zheng, Liang Li, Ying‐Cheng Yang, Guo‐Jun Hou, Xin Chen, Gui‐Juan Luo, Feng Huo, Qi‐Bin Leng, Frank J. Gonzalez, Xiao‐Qing Jiang, Hong‐Yang Wang, Lei Chen – 28 September 2017 – It is urgent that the means to improve liver regeneration (LR) be found, while mitigating the concurrent risk of hepatocarcinogenesis (HCG). Nuclear receptor corepressor 1 (NCoR1) is a co‐repressor of nuclear receptors, which regulates the expression level of metabolic genes; however, little is known about its potential contribution for LR and HCG.

A Large‐scale, multicenter serum metabolite biomarker identification study for the early detection of hepatocellular carcinoma

Ping Luo, Peiyuan Yin, Rui Hua, Yexiong Tan, Zaifang Li, Gaokun Qiu, Zhenyu Yin, Xingwang Xie, Xiaomei Wang, Wenbin Chen, Lina Zhou, Xiaolin Wang, Yanli Li, Hongsong Chen, Ling Gao, Xin Lu, Tangchun Wu, Hongyang Wang, Junqi Niu, Guowang Xu – 28 September 2017 – Hepatocellular carcinoma (HCC) is the third most lethal cancer worldwide. The lack of effective biomarkers for the early detection of HCC results in unsatisfactory curative treatments. Here, metabolite biomarkers were identified and validated for HCC diagnosis.

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