Distinct role of nuclear receptor corepressor 1 regulated de novo fatty acids synthesis in liver regeneration and hepatocarcinogenesis in mice

Qing Ou‐Yang, Xi‐Meng Lin, Yan‐Jing Zhu, Bo Zheng, Liang Li, Ying‐Cheng Yang, Guo‐Jun Hou, Xin Chen, Gui‐Juan Luo, Feng Huo, Qi‐Bin Leng, Frank J. Gonzalez, Xiao‐Qing Jiang, Hong‐Yang Wang, Lei Chen – 28 September 2017 – It is urgent that the means to improve liver regeneration (LR) be found, while mitigating the concurrent risk of hepatocarcinogenesis (HCG). Nuclear receptor corepressor 1 (NCoR1) is a co‐repressor of nuclear receptors, which regulates the expression level of metabolic genes; however, little is known about its potential contribution for LR and HCG.

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