Glecaprevir/pibrentasvir for hepatitis C virus genotype 3 patients with cirrhosis and/or prior treatment experience: A partially randomized phase 3 clinical trial

David Wyles, Fred Poordad, Stanley Wang, Laurent Alric, Franco Felizarta, Paul Y. Kwo, Benedict Maliakkal, Kosh Agarwal, Tarek Hassanein, Frank Weilert, Samuel S. Lee, Jens Kort, Sandra S. Lovell, Ran Liu, Chih‐Wei Lin, Tami Pilot‐Matias, Preethi Krishnan, Federico J. Mensa – 19 September 2017 – This study assessed the efficacy and safety of ribavirin‐free coformulated glecaprevir/pibrentasvir (G/P) in patients with hepatitis C virus genotype 3 infection with prior treatment experience and/or compensated cirrhosis, a patient population with limited treatment options.

New pediatric percentiles of liver enzyme serum levels (alanine aminotransferase, aspartate aminotransferase, γ‐glutamyltransferase): Effects of age, sex, body mass index, and pubertal stage

Sarah Bussler, Mandy Vogel, Diana Pietzner, Kristian Harms, Theresa Buzek, Melanie Penke, Norman Händel, Antje Körner, Ulrich Baumann, Wieland Kiess, Gunter Flemming – 19 September 2017 – The present study aims to clarify the effects of sex, age, body mass index (BMI), and puberty on transaminase serum levels in children and adolescents and to provide new age‐ and sex‐related percentiles for alanine aminotransferase (ALT), aspartate aminotransferase (AST), and γ‐glutamyltransferase (GGT). Venous blood and anthropometric data were collected from 4,126 cases.

MicroRNA‐506 promotes primary biliary cholangitis–like features in cholangiocytes and immune activation

Oihane Erice, Patricia Munoz‐Garrido, Javier Vaquero, Maria J. Perugorria, Maite G. Fernandez‐Barrena, Elena Saez, Alvaro Santos‐Laso, Ander Arbelaiz, Raul Jimenez‐Agüero, Joaquin Fernandez‐Irigoyen, Enrique Santamaria, Verónica Torrano, Arkaitz Carracedo, Meenakshisundaram Ananthanarayanan, Marco Marzioni, Jesus Prieto, Ulrich Beuers, Ronald P. Oude Elferink, Nicholas F. LaRusso, Luis Bujanda, Jose J.G. Marin, Jesus M.

Validation of artificial neural networks as a methodology for donor‐recipient matching for liver transplantation

María Dolores Ayllón, Rubén Ciria, Manuel Cruz‐Ramírez, María Pérez‐Ortiz, Irene Gómez, Roberto Valente, John O'Grady, Manuel de la Mata, César Hervás‐Martínez, Nigel D. Heaton, Javier Briceño – 16 September 2017 – In 2014, we reported a model for donor‐recipient (D‐R) matching in liver transplantation (LT) based on artificial neural networks (ANNs) from a Spanish multicenter study (Model for Allocation of Donor and Recipient in España [MADR‐E]). The aim is to test the ANN‐based methodology in a different European health care system in order to validate it.

Graft‐infiltrating PD‐L1hi cross‐dressed dendritic cells regulate antidonor T cell responses in mouse liver transplant tolerance

Yoshihiro Ono, Angelica Perez‐Gutierrez, Toshimasa Nakao, Helong Dai, Geoffrey Camirand, Osamu Yoshida, Shinichiro Yokota, Donna Beer Stolz, Mark A. Ross, Adrian E. Morelli, David A. Geller, Angus W. Thomson – 16 September 2017 – Although a key role of cross‐dressing has been established in immunity to viral infection and more recently in the instigation of transplant rejection, its role in tolerance is unclear.

The interplay of type I and type II interferons in murine autoimmune cholangitis as a basis for sex‐biased autoimmunity

Heekyong R. Bae, Deborah L. Hodge, Guo‐Xiang Yang, Patrick S.C. Leung, Sathi Babu Chodisetti, Julio C. Valencia, Michael Sanford, John M. Fenimore, Ziaur S.M. Rahman, Koichi Tsuneyama, Gary L. Norman, M. Eric Gershwin, Howard A. Young – 16 September 2017 – We have reported on a murine model of autoimmune cholangitis, generated by altering the AU‐rich element (ARE) by deletion of the interferon gamma (IFN‐γ) 3' untranslated region (coined ARE‐Del−/−), that has striking similarities to human primary biliary cholangitis (PBC) with female predominance.

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