Protein arginine methyl transferase 1– and Jumonji C domain‐containing protein 6–dependent arginine methylation regulate hepatocyte nuclear factor 4 alpha expression and hepatocyte proliferation in mice

Jie Zhao, Abby Adams, Ben Roberts, Maura O'Neil, Anusha Vittal, Timothy Schmitt, Sean Kumer, Josiah Cox, Zhuan Li, Steven A. Weinman, Irina Tikhanovich – 10 October 2017 – Alcohol is a well‐established risk factor for hepatocellular carcinoma (HCC), but the mechanisms by which it promotes liver cancer are not well understood. Several studies have shown that cellular protein arginine methylation is inhibited by alcohol.

The rise of the opioid epidemic and hepatitis C–positive organs: A new era in liver transplantation

Stevan A. Gonzalez, James F. Trotter – 10 October 2017 – The use of hepatitis C virus (HCV)‐positive organs in liver transplantation (LT) has increased in the era of direct‐acting antiviral therapy. A rising demand for organs, the increased ability to effectively treat HCV infection in the transplant setting, and an unprecedented increase in HCV‐positive donors have all contributed to this trend. A recent abrupt rise in opioid use in the United States has resulted in a surge of injection drug use, transmission of HCV, and opioid‐related overdose deaths.

Genetic diversity and worldwide distribution of the deltavirus genus: A study of 2,152 clinical strains

Frédéric Le Gal, Ségolène Brichler, Tudor Drugan, Chakib Alloui, Dominique Roulot, Jean‐Michel Pawlotsky, Paul Dény, Emmanuel Gordien – 9 October 2017 – Hepatitis delta virus (HDV) is responsible for the most severe form of acute and chronic viral hepatitis. We previously proposed that the Deltavirus genus is composed of eight major clades. However, few sequences were available to confirm this classification. Moreover, little is known about the structural and functional consequences of HDV variability.

Role of aramchol in steatohepatitis and fibrosis in mice

Marta Iruarrizaga‐Lejarreta, Marta Varela‐Rey, David Fernández‐Ramos, Ibon Martínez‐Arranz, Teresa C Delgado, Jorge Simon, Virginia Gutiérrez‐de Juan, Laura delaCruz‐Villar, Mikel Azkargorta, José L. Lavin, Rebeca Mayo, Sebastiaan M. Van Liempd, Igor Aurrekoetxea, Xabier Buqué, Donatella Delle Cave, Arantza Peña, Juan Rodríguez‐Cuesta, Ana M. Aransay, Felix Elortza, Juan M. Falcón‐Pérez, Patricia Aspichueta, Liat Hayardeny, Mazen Noureddin, Arun J. Sanyal, Cristina Alonso, Juan Anguita, María Luz Martínez‐Chantar, Shelly C. Lu, José M.

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