Dual catenin loss in murine liver causes tight junctional deregulation and progressive intrahepatic cholestasis

Tirthadipa Pradhan‐Sundd, Lili Zhou, Ravi Vats, An Jiang, Laura Molina, Sucha Singh, Minakshi Poddar, Jacquelyn Russell, Donna B Stolz, Michael Oertel, Udayan Apte, Simon Watkins, Sarangarajan Ranganathan, Kari N. Nejak‐Bowen, Prithu Sundd, Satdarshan Pal Monga – 10 October 2017 – β‐Catenin, the downstream effector of the Wnt signaling, plays important roles in hepatic development, regeneration, and tumorigenesis. However, its role at hepatocyte adherens junctions (AJ) is relatively poorly understood, chiefly due to spontaneous compensation by γ‐catenin.

Nonalcoholic fatty liver disease impairs expression of the type II inositol 1,4,5‐trisphosphate receptor

Tanaporn Khamphaya, Natsasi Chukijrungroat, Vitoon Saengsirisuwan, Kisha A. Mitchell‐Richards, Marie E. Robert, Albert Mennone, Meenakshisundaram Ananthanarayanan, Michael H. Nathanson, Jittima Weerachayaphorn – 10 October 2017 – Nonalcoholic fatty liver disease (NAFLD) is the most prevalent liver disease worldwide. It may result in several types of liver problems, including impaired liver regeneration (LR), but the mechanism for this is unknown.

Cell death markers in patients with cirrhosis and acute decompensation

Stewart Macdonald, Fausto Andreola, Patrik Bachtiger, Alex Amoros, Marco Pavesi, Rajeshwar Mookerjee, Yu Bao Zheng, Henning Gronbaek, Alexander L. Gerbes, Elsa Sola, Paolo Caraceni, Richard Moreau, Pere Gines, Vicente Arroyo, Rajiv Jalan – 10 October 2017 – The aims of this study were to determine the role of cell death in patients with cirrhosis and acute decompensation (AD) and acute on chronic liver failure (ACLF) using plasma‐based biomarkers.

Protein arginine methyl transferase 1– and Jumonji C domain‐containing protein 6–dependent arginine methylation regulate hepatocyte nuclear factor 4 alpha expression and hepatocyte proliferation in mice

Jie Zhao, Abby Adams, Ben Roberts, Maura O'Neil, Anusha Vittal, Timothy Schmitt, Sean Kumer, Josiah Cox, Zhuan Li, Steven A. Weinman, Irina Tikhanovich – 10 October 2017 – Alcohol is a well‐established risk factor for hepatocellular carcinoma (HCC), but the mechanisms by which it promotes liver cancer are not well understood. Several studies have shown that cellular protein arginine methylation is inhibited by alcohol.

The rise of the opioid epidemic and hepatitis C–positive organs: A new era in liver transplantation

Stevan A. Gonzalez, James F. Trotter – 10 October 2017 – The use of hepatitis C virus (HCV)‐positive organs in liver transplantation (LT) has increased in the era of direct‐acting antiviral therapy. A rising demand for organs, the increased ability to effectively treat HCV infection in the transplant setting, and an unprecedented increase in HCV‐positive donors have all contributed to this trend. A recent abrupt rise in opioid use in the United States has resulted in a surge of injection drug use, transmission of HCV, and opioid‐related overdose deaths.

Genetic diversity and worldwide distribution of the deltavirus genus: A study of 2,152 clinical strains

Frédéric Le Gal, Ségolène Brichler, Tudor Drugan, Chakib Alloui, Dominique Roulot, Jean‐Michel Pawlotsky, Paul Dény, Emmanuel Gordien – 9 October 2017 – Hepatitis delta virus (HDV) is responsible for the most severe form of acute and chronic viral hepatitis. We previously proposed that the Deltavirus genus is composed of eight major clades. However, few sequences were available to confirm this classification. Moreover, little is known about the structural and functional consequences of HDV variability.

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