Payal Arora, Amartya Basu, M. Lee Schmidt, Geoffrey J. Clark, Howard Donninger, Daniel B. Nichols, Diego F. Calvisi, Neerja Kaushik‐Basu – 16 January 2017 – Hepatitis C virus (HCV) infection is a common risk factor for the development of liver cancer. The molecular mechanisms underlying this effect are only partially understood. Here, we show that the HCV protein, nonstructural protein (NS) 5B, directly binds to the tumor suppressor, NORE1A (RASSF5), and promotes its proteosomal degradation.

Lei Hei, Jin Zhong – 16 January 2017 – Retinoic acid‐inducible gene I (RIG‐I)‐like receptors are cytosolic pattern recognition receptors (PRRs) that detect non‐self‐RNA and activate downstream interferon (IFN) signaling. One of the RIG‐I‐like receptors, laboratory of genetics and physiology 2 (LGP2), was originally thought to be a negative feedback regulator in the RIG‐I signaling pathway, but growing evidence indicates that LGP2 is one cofactor of melanoma differentiation‐associated protein 5 (MDA5) in MDA5‐mediated IFN signaling activation.

Jin‐Kyu Park, Mingjie Shao, Moon Young Kim, Soon Koo Baik, Mee Yon Cho, Teruo Utsumi, Ayano Satoh, Xinsho Ouyang, Chuhan Chung, Yasuko Iwakiri – 16 January 2017 – Nogo‐B (Reticulon 4B) is an endoplasmic reticulum (ER) resident protein that regulates ER structure and function. Because ER stress is known to induce M2 macrophage polarization, we examined whether Nogo‐B regulates M1/M2 polarization of Kupffer cells and alters the pathogenesis of alcoholic liver disease (ALD).

Michael A. Nalesnik, Chandrashekhar R. Gandhi, Thomas E. Starzl – 13 January 2017

Amedeo Lonardo, Fabio Nascimbeni, Stefano Ballestri – 13 January 2017

Michael A. Nalesnik, Chandrashekhar R. Gandhi, Thomas E. Starzl – 13 January 2017

Eun‐Jeong Joo, Yoosoo Chang, Seungho Ryu – 13 January 2017

Felix Gundling, Maximilian Tiller, Wolfgang Schepp – 11 January 2017

Nicolas Goldaracena, Nazia Selzner, Markus Selzner – 10 January 2017

Jung Eun Jang, Han‐Sol Park, Hyun Ju Yoo, In‐Jeoung Baek, Ji Eun Yoon, Myoung Seok Ko, Ah‐Ram Kim, Hyoun Sik Kim, Hye‐Sun Park, Seung Eun Lee, Seung‐Whan Kim, Su Jung Kim, Jaechan Leem, Yu Mi Kang, Min Kyo Jung, Chan‐Gi Pack, Chong Jai Kim, Chang Ohk Sung, In‐Kyu Lee, Joong‐Yeol Park, José C. Fernández‐Checa, Eun Hee Koh, Ki‐Up Lee – 10 January 2017 – Free cholesterol (FC) accumulation in the liver is an important pathogenic mechanism of nonalcoholic steatohepatitis (NASH).