An endogenous DNA adduct as a prognostic biomarker for hepatocarcinogenesis and its prevention by Theaphenon E in mice

Ying Fu, Shana Silverstein, Justine N. McCutcheon, Marcin Dyba, Raghu G. Nath, Monika Aggarwal, Heidi Coia, Angela Bai, Jishen Pan, Jiji Jiang, Bhaskar Kallakury, Hongkun Wang, Yu‐Wen Zhang, Giuseppe Giaccone, Aiwu Ruth He, Fung‐Lung Chung – 18 July 2017 – Hepatocellular carcinoma (HCC) is the third leading cause of cancer–related deaths worldwide, mainly because of its poor prognosis. A valid mechanism‐based prognostic biomarker is urgently needed. γ‐hydroxy‐1,N2‐propanodeoxyguanosine (γ‐OHPdG) is an endogenously formed mutagenic DNA adduct derived from lipid peroxidation.

Fibrosis in small syngeneic rat liver grafts because of damaged bone marrow stem cells from chronic alcohol consumption

Masayuki Hisada, Xiuying Zhang, Yoshihiro Ota, Andrew M. Cameron, James Burdick, Bin Gao, George Melville Williams, Zhaoli Sun – 18 July 2017 – A patient with liver failure due to chronic and acute alcohol abuse under consideration for an urgent liver transplant shortly after stopping alcohol may have residual abnormalities that threaten transplant success, particularly for a small graft.

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