Value‐based care in hepatology

Mario Strazzabosco, John I. Allen, Elizabeth O. Teisberg – 10 January 2017 – The migration from legacy fee‐for‐service reimbursement to payments linked to high‐value health care is accelerating in the United States because of new legislation and redesign of payments from the Centers for Medicare and Medicaid Services. Because patients with chronic diseases account for substantial use of health care resources, payers and health systems are focusing on maximizing the value of care for these patients.

Value‐based care in hepatology

Mario Strazzabosco, John I. Allen, Elizabeth O. Teisberg – 10 January 2017 – The migration from legacy fee‐for‐service reimbursement to payments linked to high‐value health care is accelerating in the United States because of new legislation and redesign of payments from the Centers for Medicare and Medicaid Services. Because patients with chronic diseases account for substantial use of health care resources, payers and health systems are focusing on maximizing the value of care for these patients.

Protective role of endogenous plasmalogens against hepatic steatosis and steatohepatitis in mice

Jung Eun Jang, Han‐Sol Park, Hyun Ju Yoo, In‐Jeoung Baek, Ji Eun Yoon, Myoung Seok Ko, Ah‐Ram Kim, Hyoun Sik Kim, Hye‐Sun Park, Seung Eun Lee, Seung‐Whan Kim, Su Jung Kim, Jaechan Leem, Yu Mi Kang, Min Kyo Jung, Chan‐Gi Pack, Chong Jai Kim, Chang Ohk Sung, In‐Kyu Lee, Joong‐Yeol Park, José C. Fernández‐Checa, Eun Hee Koh, Ki‐Up Lee – 10 January 2017 – Free cholesterol (FC) accumulation in the liver is an important pathogenic mechanism of nonalcoholic steatohepatitis (NASH).

Ammonia mediates cortical hemichannel dysfunction in rodent models of chronic liver disease

Anna Hadjihambi, Francesco Chiara, Patrick S. Hosford, Abeba Habtetion, Anastassios Karagiannis, Nathan Davies, Alexander V. Gourine, Rajiv Jalan – 9 January 2017 – The pathogenesis of hepatic encephalopathy (HE) in cirrhosis is multifactorial and ammonia is thought to play a key role. Astroglial dysfunction is known to be present in HE. Astrocytes are extensively connected by gap junctions formed of connexins, which also exist as functional hemichannels allowing exchange of molecules between the cytoplasm and the extracellular milieu.

Knockout of the primary sclerosing cholangitis‐risk gene Fut2 causes liver disease in mice

Luca Maroni, Simon D. Hohenester, Stan F.J. van de Graaf, Dagmar Tolenaars, Krijn van Lienden, Joanne Verheij, Marco Marzioni, Tom H. Karlsen, Ronald P.J. Oude Elferink, Ulrich Beuers – 5 January 2017 – The etiopathogenesis of primary sclerosing cholangitis is unknown. Genetic variants of fucosyltransferase 2 (FUT2) have been identified in genome‐wide association studies as risk factors for primary sclerosing cholangitis. We investigated the role of Fut2 in murine liver pathophysiology by studying Fut2–/– mice.

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