Central role of the TIR‐domain‐containing adaptor‐inducing interferon‐β (TRIF) adaptor protein in murine sterile liver injury

Katherine J. Brempelis, Sebastian Y. Yuen, Nicole Schwarz, Isaac Mohar, Ian N. Crispe – 24 January 2017 – Multiple pathways drive the sterile injury response in the liver; however, it is unclear how the type of cells injured or the mechanism of injury activates these pathways. Here, we use a model of selective hepatocyte death to investigate sterile liver injury.

The role of sphingosine 1‐phosphate receptor 2 in bile‐acid–induced cholangiocyte proliferation and cholestasis‐induced liver injury in mice

Yongqing Wang, Hiroaki Aoki, Jing Yang, Kesong Peng, Runping Liu, Xiaojiaoyang Li, Xiaoyan Qiang, Lixin Sun, Emily C. Gurley, Guanhua Lai, Luyong Zhang, Guang Liang, Masayuki Nagahashi, Kazuaki Takabe, William M. Pandak, Phillip B. Hylemon, Huiping Zhou – 24 January 2017 – Bile duct obstruction is a potent stimulus for cholangiocyte proliferation, especially for large cholangiocytes.

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