Jian Sun, Enshuang Guo, Jiankun Yang, Yan Yang, Shenpei Liu, Jifa Hu, Xiaojing Jiang, Olaf Dirsch, Uta Dahmen, Wei Dong, Anding Liu – 30 January 2017 – Carbon monoxide (CO) exerts protective effects on hepatic ischemia/reperfusion injury (IRI), but the underlying molecular mechanisms are not fully understood. High‐mobility group box 1 (HMGB1) is an important mediator of injury and inflammation in hepatic IRI. Here, we investigated whether CO could attenuate hepatic IRI via inhibition of HMGB1 release, particularly through sirtuin 1 (SIRT1).

Yan Wang, Robert Vincent, Jinlian Yang, Amon Asgharpour, Xieer Liang, Michael O. Idowu, Melissa J. Contos, Kalyani Daitya, Mohammed S. Siddiqui, Faridoddin Mirshahi, Arun J. Sanyal – 30 January 2017 – There is a need for further refinement of current histological systems for assessment of hepatic fibrosis in nonalcoholic fatty liver disease (NAFLD). This study evaluated hepatic fibrosis in NAFLD using dual‐photon microscopy‐based quantitation of fibrosis‐related parameters (q‐FPs).

Christian Loeffelholz, Stefanie Lieske, Frank Neuschäfer‐Rube, Diana M. Willmes, Nathanael Raschzok, Igor M. Sauer, Jörg König, Martin F. Fromm, Paul Horn, Antonios Chatzigeorgiou, Andrea Pathe‐Neuschäfer‐Rube, Jens Jordan, Andreas F.H. Pfeiffer, Geltrude Mingrone, Stefan R. Bornstein, Peter Stroehle, Christoph Harms, F. Thomas Wunderlich, Stephen L. Helfand, Michel Bernier, Rafael Cabo, Gerald I. Shulman, Triantafyllos Chavakis, Gerhard P. Püschel, Andreas L.

Daniel Katz, Jeron Zerillo, Sang Kim, Bryan Hill, Ryan Wang, Andrew Goldberg, Samuel DeMaria – 30 January 2017 – Anesthetic management of orthotopic liver transplantation (OLT) is complex. Given the unequal distributions of liver transplant surgeries performed at different centers, anesthesiology providers receive relatively uneven OLT training and exposure. One well‐suited modality for OLT training is the “serious game,” an interactive application created for the purpose of imparting knowledge or skills, while leveraging the self‐motivating elements of video games.

Alex N. Gordon‐Weeks, Su Y. Lim, Arseniy E. Yuzhalin, Keaton Jones, Bostjan Markelc, K. Jin Kim, Jon N. Buzzelli, Emmanouil Fokas, Yunhong Cao, Sean Smart, Ruth Muschel – 30 January 2017 – Hepatic metastases are amenable to ablation; however, many patients are not suitable candidates for such therapy and recurrence is common. The tumor microenvironment is known to be essential for metastatic growth, yet identification of plausible targets for cancer therapy in the microenvironment has proven elusive.

Siddharth Sood, Craig Haifer, Lijia Yu, Julie Pavlovic, Leonid Churilov, Paul J. Gow, Robert M. Jones, Peter W. Angus, Kumar Visvanathan, Adam G. Testro – 30 January 2017 – Balancing immunosuppression after liver transplant is difficult, with clinical events common. We investigate whether a novel immune biomarker based on a laboratory platform with widespread availability that measures interferon γ (IFNγ) after stimulation with a lyophilized ball containing an adaptive and innate immune stimulant can predict events following transplantation.

Parambir S. Dulai, Siddharth Singh, Janki Patel, Meera Soni, Larry J. Prokop, Zobair Younossi, Giada Sebastiani, Mattias Ekstedt, Hannes Hagstrom, Patrik Nasr, Per Stal, Vincent Wai‐Sun Wong, Stergios Kechagias, Rolf Hultcrantz, Rohit Loomba – 28 January 2017 – Liver fibrosis is the most important predictor of mortality in nonalcoholic fatty liver disease (NAFLD). Quantitative risk of mortality by fibrosis stage has not been systematically evaluated. We aimed to quantify the fibrosis stage–specific risk of all‐cause and liver‐related mortality in NAFLD.

Julie K. Heimbach, Laura M. Kulik, Richard S. Finn, Claude B. Sirlin, Michael M. Abecassis, Lewis R. Roberts, Andrew X. Zhu, M. Hassan Murad, Jorge A. Marrero – 28 January 2017

Parambir S. Dulai, Siddharth Singh, Janki Patel, Meera Soni, Larry J. Prokop, Zobair Younossi, Giada Sebastiani, Mattias Ekstedt, Hannes Hagstrom, Patrik Nasr, Per Stal, Vincent Wai‐Sun Wong, Stergios Kechagias, Rolf Hultcrantz, Rohit Loomba – 28 January 2017 – Liver fibrosis is the most important predictor of mortality in nonalcoholic fatty liver disease (NAFLD). Quantitative risk of mortality by fibrosis stage has not been systematically evaluated. We aimed to quantify the fibrosis stage–specific risk of all‐cause and liver‐related mortality in NAFLD.

Julie K. Heimbach, Laura M. Kulik, Richard S. Finn, Claude B. Sirlin, Michael M. Abecassis, Lewis R. Roberts, Andrew X. Zhu, M. Hassan Murad, Jorge A. Marrero – 28 January 2017