Futility of care in patients with acute‐on‐chronic liver failure
Filipe S. Cardoso, Rui Pereira, Gonçalo Alexandrino, Luís Bagulho – 13 February 2017
Galectin‐9: Diverse roles in hepatic immune homeostasis and inflammation
Lucy Golden‐Mason, Hugo R. Rosen – 13 February 2017 – Glycan‐binding proteins, which include galectins, are involved at all stages of immunity and inflammation, from initiation through resolution. Galectin‐9 (Gal‐9) is highly expressed in the liver and has a wide variety of biological functions in innate and adaptive immunity that are instrumental in the maintenance of hepatic homeostasis. In the setting of viral hepatitis, increased expression of Gal‐9 drives the expansion of regulatory T cells and contraction of effector T cells, thereby favoring viral persistence.
Hepatitis B reactivation in hepatitis B and C coinfected patients treated with antiviral agents: A systematic review and meta‐analysis
Guofeng Chen, Cheng Wang, Jing Chen, Dong Ji, Yudong Wang, Vanessa Wu, Johan Karlberg, George Lau – 13 February 2017 – There is an increased awareness of hepatitis B (HBV) reactivation in chronic hepatitis C (CHC) patients coinfected with HBV treated with pan‐oral direct‐acting antiviral agents (DAAs).
MR lymphography of hepatic lymphatic system
Lionel Arrivé, Sanaâ Mouhadi – 13 February 2017
Left ventricular systolic function is associated with sympathetic nervous activity and markers of inflammation in cirrhosis
Raquel Yotti, Cristina Ripoll, Yolanda Benito, Maria Vega Catalina, Jaime Elízaga, Diego Rincón, Francisco Fernández‐Avilés, Javier Bermejo, Rafael Bañares – 13 February 2017 – An accurate evaluation of cardiac function in patients with cirrhosis remains a challenge. We used robust echocardiographic indices to characterize left ventricular (LV) systolic function and its relationship to activation of the sympathetic nervous system and inflammation in 59 patients with cirrhosis and 59 age‐matched controls.
Patient understanding of hepatocellular carcinoma surveillance
Matthew A. Goldsworthy, Ian A. Rowe – 13 February 2017
Prioritization for liver transplantation: Reconsidering survival benefit
Andrew P. Keaveny, C. Burcin Taner – 13 February 2017
Sodium taurocholate cotransporting polypeptide is the limiting host factor of hepatitis B virus infection in macaque and pig hepatocytes
Florian A. Lempp, Ellen Wiedtke, Bingqian Qu, Pierre Roques, Isabelle Chemin, Florian W. R. Vondran, Roger Le Grand, Dirk Grimm, Stephan Urban – 13 February 2017 – Infections with the human hepatitis B virus (HBV) and hepatitis D virus (HDV) depend on species‐specific host factors like the receptor human sodium taurocholate cotransporting polypeptide (hNTCP). Complementation of mouse hepatocytes with hNTCP confers susceptibility to HDV but not HBV, indicating the requirement of additional HBV‐specific factors.
On beyond staging and grading: Liver biopsy evaluation in a posttreatment world
David E. Kleiner – 13 February 2017
Ammonia lowering reverses sarcopenia of cirrhosis by restoring skeletal muscle proteostasis
Avinash Kumar, Gangarao Davuluri, Rafaella Nascimento e Silva, Marielle P.K.J. Engelen, Gabrie A.M. Ten Have, Richard Prayson, Nicolaas E.P. Deutz, Srinivasan Dasarathy – 13 February 2017 – Sarcopenia or skeletal muscle loss is a frequent, potentially reversible complication in cirrhosis that adversely affects clinical outcomes. Hyperammonemia is a consistent abnormality in cirrhosis that results in impaired skeletal muscle protein synthesis and breakdown (proteostasis).