Jonathan J. Hogan, Mary Ann Lim, Matthew B. Palmer, Roy D. Bloom, Raymond T. Chung, Meghan E. Sise – 17 February 2017
Behnam Saberi, Alia S. Dadabhai, Christine M. Durand, Benjamin Philosophe, Andrew M. Cameron, Mark S. Sulkowski, Ahmet Gurakar – 17 February 2017
Ruud M. Buijs, Natali Guerrero‐Vargas – 15 February 2017
Hao Li, Zun‐Qiang Zhou, Zhang‐Ru Yang, Da‐Nian Tong, Jiao Guan, Bao‐Jie Shi, Jia Nie, Xian‐Ting Ding, Bin Li, Guang‐Wen Zhou, Zheng‐Yun Zhang – 14 February 2017 – Current treatment of intrahepatic cholangiocarcinoma (ICC) remains ineffective because knowledge of ICC carcinogenesis is unclear. Increasing evidence suggests that microRNAs (miRNAs), including miR‐191, play an important role in tumorigenesis; but expression and biological functions of miR‐191 in ICC remain to be established. This study investigated the functions and underlying mechanisms of miR‐191 in ICC.
Xavier Forns – 14 February 2017
Lei Xu, Wenshi Wang, Yunlong Li, Xinying Zhou, Yuebang Yin, Yijin Wang, Robert A. de Man, Luc J.W. van der Laan, Fen Huang, Nassim Kamar, Maikel P. Peppelenbosch, Qiuwei Pan – 13 February 2017 – Interferons (IFNs) are broad antiviral cytokines that exert their function by inducing the transcription of hundreds of IFN‐stimulated genes (ISGs). However, little is known about the antiviral potential of these cellular effectors on hepatitis E virus (HEV) infection, the leading cause of acute hepatitis globally.
Yasuko Iwakiri – 13 February 2017
Aynur Unalp‐Arida, Constance E. Ruhl – 13 February 2017 – Fatty liver disease is common in the United States and worldwide due to changing lifestyles and can progress to fibrosis and cirrhosis contributing to premature death. We examined whether liver fibrosis scores were associated with increased overall and disease‐specific mortality in a United States population–based prospective survey with up to 23 years of linked‐mortality data. Data were analyzed from 14,841 viral hepatitis–negative adult participants in the third National Health and Nutrition Examination Survey, 1988‐1994.
Lucy Golden‐Mason, Hugo R. Rosen – 13 February 2017 – Glycan‐binding proteins, which include galectins, are involved at all stages of immunity and inflammation, from initiation through resolution. Galectin‐9 (Gal‐9) is highly expressed in the liver and has a wide variety of biological functions in innate and adaptive immunity that are instrumental in the maintenance of hepatic homeostasis. In the setting of viral hepatitis, increased expression of Gal‐9 drives the expansion of regulatory T cells and contraction of effector T cells, thereby favoring viral persistence.
Hao Wang, Peng An, Enjun Xie, Qian Wu, Xuexian Fang, Hong Gao, Zhuzhen Zhang, Yuzhu Li, Xudong Wang, Jiaying Zhang, Guoli Li, Lei Yang, Wei Liu, Junxia Min, Fudi Wang – 13 February 2017 – Ferroptosis is a recently identified iron‐dependent form of nonapoptotic cell death implicated in brain, kidney, and heart pathology. However, the biological roles of iron and iron metabolism in ferroptosis remain poorly understood. Here, we studied the functional role of iron and iron metabolism in the pathogenesis of ferroptosis.