Gut microbial composition can differentially regulate bile acid synthesis in humanized mice

Dae Joong Kang, Phillip B Hylemon, Patrick M Gillevet, R. Balfour Sartor, Naga S. Betrapally, Genta Kakiyama, Masoumeh Sikaroodi, Hajime Takei, Hiroshi Nittono, Huiping Zhou, William M. Pandak, Jing Yang, Chunhua Jiao, Xiaojiaoyang Li, H. Robert Lippman, Douglas M. Heuman, Jasmohan S. Bajaj – 27 February 2017 – We previously reported that alcohol drinkers with and without cirrhosis showed a significant increase in fecal bile acid secretion compared to nondrinkers.

microRNA‐200a: A stage‐dependent biomarker and predictor of steatosis and liver cell injury in human immunodeficiency virus patients

Christian Austermann, Robert Schierwagen, Raphael Mohr, Evrim Anadol, Sabine Klein, Alessandra Pohlmann, Christian Jansen, Christian P. Strassburg, Carolynne Schwarze‐Zander, Christoph Boesecke, Jürgen K. Rockstroh, Margarete Odenthal, Jonel Trebicka – 27 February 2017 – Nonalcoholic fatty liver disease contributes to liver‐related mortality and has a high prevalence among patients with human immunodeficiency virus (HIV). The early detection of steatosis could prevent disease progression through life‐style changes.

Liver transplant modulates gut microbial dysbiosis and cognitive function in cirrhosis

Jasmohan S. Bajaj, Andrew Fagan, Masoumeh Sikaroodi, Melanie B. White, Richard K. Sterling, HoChong Gilles, Douglas Heuman, Richard T. Stravitz, Scott C. Matherly, Mohammed S. Siddiqui, Puneet Puri, Arun J. Sanyal, Velimir Luketic, Binu John, Michael Fuchs, Vishwadeep Ahluwalia, Patrick M. Gillevet – 27 February 2017 – Liver transplantation (LT) improves daily function and cognition in patients with cirrhosis, but a subset of patients can remain impaired.

Effects of a sodium‐glucose cotransporter 2 inhibitor in nonalcoholic fatty liver disease complicated by diabetes mellitus: Preliminary prospective study based on serial liver biopsies

Norio Akuta, Chizuru Watanabe, Yusuke Kawamura, Yasuji Arase, Satoshi Saitoh, Shunichiro Fujiyama, Hitomi Sezaki, Tetsuya Hosaka, Masahiro Kobayashi, Mariko Kobayashi, Yoshiyuki Suzuki, Fumitaka Suzuki, Kenji Ikeda, Hiromitsu Kumada – 27 February 2017 – A prospective study based on serial liver biopsies was performed to investigate the efficacy of sodium‐glucose cotransporter 2 inhibitor for nonalcoholic fatty liver disease complicated with type 2 diabetes mellitus. Conclusion: Treatment for 24 weeks resulted in improvement in histopathologic features in all 5 patients.

Liver ex situ machine perfusion preservation: A review of the methodology and results of large animal studies and clinical trials

Hazel Marecki, Adel Bozorgzadeh, Robert J. Porte, Henri G. Leuvenink, Korkut Uygun, Paulo N. Martins – 27 February 2017 – Ex vivo machine perfusion (MP) is a promising way to better preserve livers prior to transplantation. Currently, no methodology has a verified benefit over simple cold storage. Before becoming clinically feasible, MP requires validation in models that reliably predict human performance. Such a model has been found in porcine liver, whose physiological, anatomical, and immunological characteristics closely resemble the human liver.

Genetic, hematological, and immunological disorders transmissible with liver transplantation

Amy Tan, Sander S. Florman, Thomas D. Schiano – 27 February 2017 – It is well recognized that solid organ transplantation can transmit bacterial infection and chronic viral hepatitis as well as certain cancers. As indications for liver transplantation (LT) have expanded, it has been used to treat and even cure certain genetic cholestatic disorders, urea cycle defects, and coagulation abnormalities; many of these conditions are potentially transmissible with LT as well.

Reconstruction of Anomalous Portal Venous Branching in Right Lobe Living Donor Liver Transplantation: Malatya Approach

Sezai Yilmaz, Cuneyt Kayaalp, Burak Isik, Veysel Ersan, Emrah Otan, Sami Akbulut, Abuzer Dirican, Ramazan Kutlu, Aysegul Sagir Kahraman, Cengiz Ara, Mehmet Yilmaz, Bulent Unal, Cemalettin Aydin, Turgut Piskin, Dincer Ozgor, Mustafa Ates, Fatih Ozdemir, Volkan Ince, Cemalettin Koc, Adil Baskiran, Sait Murat Dogan, Bora Barut, Fatih Sumer, Serdar Karakas, Koray Kutluturk, Saim Yologlu, Harika Gozukara – 27 February 2017 – Reconstruction of anomalous portal vein branching (APVB) during right lobe living donor liver transplantation (LDLT) can be challenging.

Nonalcoholic fatty liver disease‐related cirrhosis is commonly unrecognized and associated with hepatocellular carcinoma

Luis C. Bertot, Gary P. Jeffrey, Michael Wallace, Gerry MacQuillan, George Garas, Helena L. Ching, Leon A. Adams – 27 February 2017 – Determination of cirrhosis in nonalcoholic fatty liver disease (NAFLD) is important as it alters prognosis and management. We aimed to examine whether cirrhosis was diagnosed incidentally or intentionally in patients with NAFLD.

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