Fernando Bril, Kenneth Cusi – 13 March 2017

Christine M. Hunt, Julie I. Papay, Vid Stanulovic, Arie Regev – 13 March 2017 – Drug‐induced hepatocellular injury is identified internationally by alanine aminotransferase (ALT) levels equal to or exceeding 5× the upper limit of normal (ULN) appearing within 3 months of drug initiation, after alternative causes are excluded. Upon withdrawing the suspect drug, ALT generally decrease by 50% or more. With drug readministration, a positive rechallenge has recently been defined by an ALT level of 3‐5× ULN or greater.

Marie Sinclair, Anthony Schelleman, Daljean Sandhu, Peter W. Angus – 13 March 2017 – We report a case of dramatic systemic inflammatory symptoms and biochemical signs of inflammation related to multiple hepatic adenomas that completely resolved after cessation of the oral contraceptive pill (OCP) and associated adenoma regression. This represents a case of dramatic symptoms that resolved after estrogen withdrawal alone. (Hepatology 2017;66:989–991).

Christine M. Hunt, Julie I. Papay, Vid Stanulovic, Arie Regev – 13 March 2017 – Drug‐induced hepatocellular injury is identified internationally by alanine aminotransferase (ALT) levels equal to or exceeding 5× the upper limit of normal (ULN) appearing within 3 months of drug initiation, after alternative causes are excluded. Upon withdrawing the suspect drug, ALT generally decrease by 50% or more. With drug readministration, a positive rechallenge has recently been defined by an ALT level of 3‐5× ULN or greater.

Marie Sinclair, Anthony Schelleman, Daljean Sandhu, Peter W. Angus – 13 March 2017 – We report a case of dramatic systemic inflammatory symptoms and biochemical signs of inflammation related to multiple hepatic adenomas that completely resolved after cessation of the oral contraceptive pill (OCP) and associated adenoma regression. This represents a case of dramatic symptoms that resolved after estrogen withdrawal alone. (Hepatology 2017;66:989–991).

Femke Stelma, Meike H. van der Ree, Marjan J. Sinnige, Anthony Brown, Leo Swadling, J. Marleen L. de Vree, Sophie B. Willemse, Marc van der Valk, Paul Grint, Steven Neben, Paul Klenerman, Eleanor Barnes, Neeltje A. Kootstra, Hendrik W. Reesink – 11 March 2017 – MicroRNA‐122 is an important host factor for the hepatitis C virus (HCV). Treatment with RG‐101, an N‐acetylgalactosamine‐conjugated anti‐microRNA‐122 oligonucleotide, resulted in a significant viral load reduction in patients with chronic HCV infection. Here, we analyzed the effects of RG‐101 therapy on antiviral immunity.

Luigia Florimonte, Massimo Iavarone, Massimo Castellani, Mariagiulia Longo, Francesco Pallotti, Lorenzo Maffioli, Eva Orunesu, Riccardo Benti – 10 March 2017

Ryan J. Schulze, Karuna Rasineni, Shaun G. Weller, Micah B. Schott, Barbara Schroeder, Carol A. Casey, Mark A. McNiven – 10 March 2017 – Alcohol consumption is a well‐established risk factor for the onset and progression of fatty liver disease. An estimated 90% of heavy drinkers are thought to develop significant liver steatosis. For these reasons, an increased understanding of the molecular basis for alcohol‐induced hepatic steatosis is important.

Luigia Florimonte, Massimo Iavarone, Massimo Castellani, Mariagiulia Longo, Francesco Pallotti, Lorenzo Maffioli, Eva Orunesu, Riccardo Benti – 10 March 2017

Norie Yamada, Ryuichi Sugiyama, Sayuri Nitta, Asako Murayama, Minoru Kobayashi, Chiaki Okuse, Michihiro Suzuki, Kiyomi Yasuda, Hiroshi Yotsuyanagi, Kyoji Moriya, Kazuhiko Koike, Takaji Wakita, Takanobu Kato – 9 March 2017 – The emergence of resistance mutations in the reverse transcriptase gene of hepatitis B virus (HBV) is associated with treatment failure. Entecavir (ETV) is one of the most potent anti‐HBV reagents; it has a very low resistance rate and is used as the first‐line treatment for chronic hepatitis B.